Research paperInhibition of cytochrome P450 2E1 expression by 2-(allylthio)Pyrazine, a Potential chemoprotective agent: hepatoprotective Effects☆
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Current major degradation methods for aflatoxins: A review
2018, Trends in Food Science and TechnologyCitation Excerpt :However, we need more experiments conducted in a wide range of foodstuffs to confirm its efficacy and safety in detoxification. 2-(Allylthio) pyrazine (2-AP) is a kind of pyrazine derivative containing an allylsulfur moiety and is able to protect liver against toxicants (Kim, Kwak, & Kim, 1997). Ha, Mar, Kim, Surh and Kim (1999) reported that 2-AP obviously decreased radiolabeled AFB1 in the liver of rats (5 days administration), and AFB1-N7-guanine adduct in rats urinary declined 45% after 2-AP pretreatment for 24 h.
On tautomerism of diazinones
2013, Computational and Theoretical ChemistryCitation Excerpt :Also, 1,2-diazine, pyridazine, core is present in quite a number of cytostatic drugs and fungicides [6–11]. The 1,4-pyrazine core is a building block of several antimicrobial, antimycotic, hepatoprotective, etc. agents to boot [12–14]. Pyrazines are of interest of food chemistry thanks to their significant contribution to food odors [15–17].
Chlorella vulgaris extract ameliorates carbon tetrachloride-induced acute hepatic injury in mice
2013, Experimental and Toxicologic PathologyCitation Excerpt :In particular, compounds or drugs that induce CYP2E1 potentiate the hepatic toxicity of CCl4 (Allis et al., 1996). On the other hand, compounds that inhibit CYP2E1 have been found to effectively inhibit CCl4-induced hepatotoxicity (Kim et al., 1997; Jeong, 1999; Lee et al., 2004; Yang et al., 2001; Fukao et al., 2004). The induction or inhibition of CCl4 biotransformation may subsequently influence the metabolic activation or detoxification of CCl4.
Evaluation of drug toxicity with hepatocytes cultured in a micro-space cell culture system
2011, Journal of Bioscience and BioengineeringCitation Excerpt :In this study, we employed acetaminophen as a test drug for hepatotoxicity. The hepatotoxicity of acetaminophen has been studied extensively and has been found to be associated with N-acetyl-p-benzoquinoneimine (NAPQI), a reactive metabolite of CYP2E1 (34). When we exposed HepG2 cells to acetaminophen, a greater reduction in cell viability was observed among cells grown in the micro-space cell culture system as compared to those grown in the monolayer system.
CYP2E1 and oxidative liver injury by alcohol
2008, Free Radical Biology and Medicine
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This work was supported in part by a Research Center for New Drug Development research grant from the Korea Science and Engineering Foundation.