Elsevier

Brain Research

Volume 769, Issue 1, 19 September 1997, Pages 163-167
Brain Research

Short communication
Effects of 2,4-dichlorophenoxyacetic acid on central nervous system of developmental rats. Associated changes in ganglioside pattern

https://doi.org/10.1016/S0006-8993(97)00823-8Get rights and content

Abstract

Neonate rats were treated with 2,4-dichlorophenoxyacetic acid (2,4-D) from the 7th or 12th until the 17th or 25th postnatal day. Two drug dosages were used: 70 and 100 mg/kg body weight of 2,4-D. At the 17th day of age, no changes were observed in body weight, protein and DNA content. However, 25-day-old treated pups showed diminutions in body and brain weight, protein and DNA levels, depending on doses and period of treatment. With respect to ganglioside levels, few changes were observed in treated animals until the 17th day of age. However, at the 25th day, with higher dose and longer treatment a diminution in all parameters analyzed was observed. These results suggest a delay in CNS development when pups were exposed to a very severe chemical injury with 2,4-D. On the other hand, when the chemical injury was not too severe, the brain would be capable to trigger biochemical mechanisms producing a plasticity response which is expressed as changes in ganglioside content and composition.

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Acknowledgements

The authors thank Aurelia Vicens of Robson for linguistic assistance. This work was partly supported by grants from the Consejo Nacional de Investigaciones Cientı́ficas y Tecnológicas (CONICET) to R.O.D.

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