Regular ArticleAstrocyte-polymer implants promote regeneration of dorsal root fibers into the adult mammalian spinal cord
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Cited by (113)
Astrocyte transplantation for spinal cord injury: Current status and perspective
2014, Brain Research BulletinCitation Excerpt :Because of the supportive benefits that astrocytes show during development (Gordon et al., 2007; Silver et al., 1982), cultured embryonic astrocytes were initially grafted with Millipore implants to serve as a substrate for axonal regrowth in a simple crush injury model of adult spinal cord (Kliot et al., 1990). Although it induced the growth of injured dorsal root fibers and limited inflammatory response around the implant, the frequency and extent of regeneration were highly variable (Kliot et al., 1990). Later studies demonstrated that grafted immature astrocytes, isolated from fetal or newborn rats, could survive, migrate, and even reduce scar volume.
Oncomodulin affords limited regeneration to injured sensory axons in vitro and in vivo
2012, Experimental NeurologyPhenotypic analysis of astrocytes derived from glial restricted precursors and their impact on axon regeneration
2012, Experimental NeurologyCitation Excerpt :In addition, it is possible that exposing of GRP to the differentiation process for a long period (beyond the 6–10 days used in our protocols) will generate a more stable phenotype. The beneficial potential of astrocytes in CNS injury has been previously demonstrated by transplantation of neonatal or embryonic astrocytes, leading to reduced lesion size and scar tissue, supporting axonal growth, and promoting recovery (Joosten et al., 2004; Kliot et al., 1990; Smith et al., 1986; Wang et al., 1995). The ongoing progress in elucidating the process of astrocyte differentiation and the characterization of different glial precursors associated with the astrocyte lineage provided efficient procedures for preparation of astrocytes for therapeutic applications.
The longitudinal spinal cord injury: Lessons from intraspinal plexus, cauda equina and medullary conus lesions
2012, Handbook of Clinical NeurologyCitation Excerpt :This is obviously a quite different mechanism than the effect of growth inhibitory molecules, but also more instructive for the neuron. Regrowth into the spinal cord after dorsal root lesion has, however, been demonstrated when growth was augmented by transplantation of glial cells (Kliot et al., 1990), conditioning lesions (Chong et al., 1999), or neurotrophic factors (Ramer et al., 2003), as well as by transplantation using olfactory ensheathing cells (OEC) (Ramon-Cueto and Nieto-Sampedro, 1994). Transplantation of OEC is known to induce regeneration and recovery in spinal cord lesions mainly by establishing a pathway (Li et al., 1997).
Clinical prospects for transplantation of OECs in the repair of brachial and lumbosacral plexus injuries: Opening a door
2011, Experimental NeurologyCitation Excerpt :However, severed dorsal roots do not re-enter the CNS, and there is consequently no recovery of touch, pain or temperature sensation, or the proprioceptive input needed for fine muscle control. There are a number of reports that severed dorsal roots can be induced to regenerate into the CNS by transplantation of glial cells (Kliot et al., 1990), conditioning nerve lesions peripheral to the dorsal root ganglia (Chong et al., 1999), or application of growth factors (Ramer et al., 2002; Wang et al., 2008). The present article will concentrate entirely on the prospects for repair by transplantation of OECs.
Cell-Cell interactions of human neural progenitor-derived astrocytes within a microstructured 3D-scaffold
2010, BiomaterialsCitation Excerpt :The intrinsic geometry of such PNS and CNS fibre pathways has been reported to play an important role in the success or failure of axons to regenerate [22]. Earlier cell implantation studies grafting immature astrocytes into experimental animals with CNS or spinal nerve root lesions (either alone or in combination with crude scaffolds composed of Millipore filters) have demonstrated some beneficial effects in terms of reduced host scarring and increased host axon regeneration [23,24,25]. More recent studies have identified that type I astroglia from the rat are capable of promoting CNS tissue repair in the absence of unwanted side-effects [11].