Journal of Molecular Biology
The process of infection with bacteriophage ΦX174: X. Mutations in a ΦX lysis gene†
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Cited by (144)
Viral replication modes in single-peak fitness landscapes: A dynamical systems analysis
2019, Journal of Theoretical BiologyCitation Excerpt :For DNA viruses, GR is the most likely mechanism of replication given their double-stranded nature, e.g., bacteriophage T2 (Luria, 1951). Exceptions maybe be single-stranded DNA viruses, such as bacteriophage ϕX174, that replicate via the SMR mode because it uses a rolling circle mechanism (Hutchison and Sinsheimer, 1966). At which point of the continuum between these two extreme modes of genome replication resides a particular virus has important evolutionary consequences.
Phage Lysis: Multiple Genes for Multiple Barriers
2019, Advances in Virus ResearchCitation Excerpt :Gram-negative hosts also are prey to small single-strand nucleic acid phages, both ssDNA and ssRNA, including phages with grand roles in the history of molecular biology like ssDNA phage phiX174 and the ssRNA phages Qβ and MS2. All of these phages accomplish lysis by a single gene, each producing a single gene lysis protein (Sgl): E for phiX174 (Hutchison III and Sinsheimer, 1966), A2 for Qβ (Karnik and Billeter, 1983; Winter and Gold, 1983), and L for MS2 (Beremand and Blumenthal, 1979). E and L are small membrane proteins (91 and 75 aa, respectively) whereas A2 is the 45 kDa virion maturation protein that is present in one copy per virion but in Qβ, doubles as the Sgl.
Plackett-Burman randomization method for Bacterial Ghosts preparation form E. coli JM109
2014, Saudi Pharmaceutical JournalCitation Excerpt :E lysis gene for BGs preparation has been well established. Simply, E lysis gene follows the Bacteriophage strategy for lysis of the cells and in fact, it is one of the Φx174 phage genes (Hutchinson and Sinsheimer, 1966; Haidinger et al., 2003). But, using such genes might have some risk factors in applications concerning the humans.
In vivo mutation analysis using the ΦX174 transgenic mouse and comparisons with other transgenes and endogenous genes
2010, Mutation Research - Reviews in Mutation ResearchCitation Excerpt :Single-burst analysis provides additional information about each mutant isolated: an estimate of the number of mutant phage produced from the first transfected cell. A “burst” of phage occurs naturally when virus particles (phage) have multiplied inside the cell (Fig. 2) and a viral protein lyses the cell wall, releasing the burst of phage [41]. ΦX174 does not contain the GATC nucleotide sequence [4] that is necessary to initiate mismatch repair in E. coli[37] and, therefore, is not subject to mismatch repair.
The untapped potential of phage model systems as therapeutic agents
2024, Virus Evolution
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The previous paper in this series was Dowell & Sinsheimer (1966).