Multiple endocrine neoplasia type 2A: A 25-year review☆
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Cited by (25)
Thyroid Disorders in Childhood and Adolescence
2008, Pediatric EndocrinologyChapter 9 Thyroid neoplasms in children and adolescents
2006, Advances in Molecular and Cellular EndocrinologyCitation Excerpt :The ideal age at which prophylactic total thyroidectomy should be performed in children with RET germline mutations is controversial. Some clinicians recommend surgery in mutation carriers of MEN 2B in the first year of life and for those with gene mutation for MEN 2A at 5 years of age [82,83]. Heptulla et al. [44] recommend prophylactic total thyroidectomy during the first decade of life in patients with FMTC and RET mutations.
Diagnosis and management of medullary thyroid carcinoma
2004, Clinics in Laboratory MedicineAcceptable age for prophylactic surgery in children with multiple endocrine neoplasia type 2a
2003, European Journal of Surgical OncologyEarly onset of medullary thyroid carcinoma in a kindred with multiple endocrine neoplasia type IIA associated with cutaneous lichen amyloidosis
2002, Endocrine PracticeCitation Excerpt :Early intervention offers the best possibility of cure, inasmuch as MTC, in classic MEN IIA kindreds, has been found as early as age 2 years (18,19) and metastatic lesions have been found at age 5 years (20). Many authorities now recommend prophylactic surgical treatment for mutation carriers at age 5 years or even earlier, although data about the long-term outcome associated with this procedure are still lacking (18-25). To the best of our knowledge, this is the earliest detection of MTC reported thus far in kindreds affected with the MEN IIA-CLA variant.
Utility of the ret prot-oncogene in the diagnosis of the hereditary medullary thyroid carcinoma. Correlation with the surgical results
2001, Acta Otorrinolaringologica Espanola
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Presented at the 29th Annual Meeting of the American Pediatric Surgical Association, Hilton Head, South Carolina, May 10–13, 1998.