Clinical and laboratory observationIntellectual development at age 12 years of children with congenital hypothyroidism diagnosed by neonatal screening+
References (11)
- et al.
Intellectual outcome in children with fetal hypothyroidism
J Pediatr
(1987) - et al.
Effect of thyroid hormone level on temperament in infants with congenital hypothyroidism detected by screening of neonates
J Pediatr
(1989) - et al.
Intellectual development in children with congenital hypothyroidism in relation to recommended thyroxine treatment
J Pediatr
(1991) - et al.
Useful parameters to predict the eventual mental outcome of hypothyroid children
Pediatr Res
(1988) The abilities of young children
(1970)
Cited by (100)
Cognitive outcome of 458 children over 25 years of neonatal screening for congenital hypothyroidism
2023, Jornal de PediatriaCongenital hypothyroidism: A historical perspective on cognitive outcome
2018, Encyclopedia of Endocrine DiseasesThyroid-related neurological disorders and complications in children
2015, Pediatric NeurologyCitation Excerpt :Studies from the Netherlands and France29,30 have shown persistent differences in IQ where patients are followed through young adulthood; this may reflect less aggressive correction of hypothyroxinemia in neonates during the early years of newborn screening than is now practiced. Also, the poorest neurodevelopmental outcomes may be associated with the most severe forms of congenital hypothyroidism31,32 (such as very low or undetectable T4 concentrations at birth), or with lower starting doses of levothyroxine replacement that result in a longer time to normalization of serum T4 in the neonate.33 Furthermore, individual subtest components of overall cognitive function may show deficits when compared with a control population; these may include domains of attention, memory, arithmetic, and verbal skills.34-36
Motherisk Rounds Fetal Pharmacotherapy 4: Fetal Thyroid Disorders
2014, Journal of Obstetrics and Gynaecology CanadaCitation Excerpt :Thyroid deficiencies in the antenatal and neonatal periods are often associated with delays in motor and mental function, as well as hearing defects later in life. In comparison, congenital hyperthyroidism is associated with high morbidity and mortality due to the incidence of high-output cardiac failure, hydrops, growth restriction, advanced bone maturation, and mental retardation.4–9 Fetal goitre is diagnosed by ultrasound during the second or third trimester.
Hypothyroidism
2009, Clinical Management of Thyroid DiseaseHypothyroidism
2008, Clinical Management of Thyroid Disease
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Supported by Fonds de la Recherche en Santé du Québec and Fondation de l'Hôpital Sainte-Justine.