Elsevier

The Journal of Pediatrics

Volume 77, Issue 5, November 1970, Pages 782-791
The Journal of Pediatrics

Original article
The cri du chat syndrome in adolescents and adults: Clinical finding in 13 older patients with partial deletion of the short arm of chromosome No. 5(5p-)*

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This study of patients aged 12 to 55 years clarifies the course of development of the 5p- syndrome. The catlike cry disappears and new features appear including strabismus, thin face, dental malocclusion, short metacarpals or metatarsals, scoliosis, small wings of the ilia, pes planus, and prematurely gray hair. Mental retardation is severe but general health good. Two of the 13 patients died and brain findings at autopsy are reported.

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  • Cited by (0)

    *

    Supported in part by Grants Nos. HD00339 and HD00516 from the National Institutes of Child Health and Human Development.

    1

    O. J. M. is a Career Scientist of the Health Research Council of the City of New York.

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