The natural history of human papillomavirus infection as measured by repeated DNA testing in adolescent and young women☆,☆☆,★,★★
Section snippets
Study Population
Beginning in October 1990, young women 13 to 22 years old were recruited from two clinic sites: Planned Parenthood and a university student health clinic. Demographics of Planned Parenthood have been described in detail previously.1 The university is a state-subsidized university located in San Francisco; ethnic and racial distribution for young women attending the university student health clinic as shown by university enrollment records at the time of recruitment was 56% white, 30%
RESULTS
Fig. 1 describes the recruitment algorithm, number of subjects screened, and final number of subjects who participated in the cohort.
The demographic and behavioral characteristics of the HPV-positive women participating in the final cohort are outlined in Table I.
Planned Parenthood (n = 325) University Health Clinic (n = 293) p Value Age at entry (yr)
DISCUSSION
Our data suggest that most young women (60% to 75%) who test positive for HPV DNA appear to become negative for that viral group type within a 20to 30-month observation period. We suggest that the prolonged DNA negativity in this study reflects actual viral elimination of a specific viral type in most women. Our data also emphasize the difficulty in defining virus negativity for purposes of epidemiologic study. With a dot-blot method with recognized limited sensitivity, negative status after
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From the Division of Adolescent Medicine, Department of Pediatrics, the Department of Epidemiology and Biostatistics, the Department of Laboratory Medicine and Stomatology, and the Department of Anatomic Pathology, University of California, San Francisco.
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Supported in part by National Cancer Institute No. R01CA51323 and No. R01CA54053, NIAIDS No. P01A121912, National Institutes of Health grant No. M01 RR01271, Maternal and Child Health Bureau Training Grant No. MCJ000978, the Cigarette and Tobacco Surtax Fund of the State of California through the Tobacco-related Research Program of the University of California, grant No. RT 487 and grant No. RT 484, AIDS Clinical Research Center, University of California, San Francisco.
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Reprint requests: Anna-Barbara Moscicki, MD, 400 Parnassus Ave., Room AC-01, Box 0503, San Francisco, CA 94143.
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