On the origin of the transfer RNA molecule

doi:10.1016/S0022-5193(05)80702-7

Journal of Theoretical Biology

Volume 159, Issue 2, 21 November 1992, Pages 199-214

https://doi.org/10.1016/S0022-5193(05)80702-7 Get rights and content

Data and arguments are given in favour of the hypothesis that the primitive tRNA molecule may have originated from a direct duplication event involving one of the two halves of the tRNA molecule. It seems that a molecule capable of assuming a hairpin structure was involved as a precursor in this duplication. The two halves of the present tRNAs could, therefore, be considered as paralogous.

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On the origin of the transfer RNA molecule

Biosystems

J. molec. Biol.

Biochimie

Curr. Opin. Genet. Dev.

Convergence and minimal mutation criteria for evaluating early events in the tRNA evolution

The evolving tRNA molecule

CRC Crit. Rev. Biochem.

A speculation on the origin of protein synthesis

Origins Life

Early evolution: transfer RNA

Evidence that introns arose at proto-splice sites

EMBO J.

The Genetic Code Mechanism and the Origin of Life

Genes in pieces: were they ever together?

Nature, Lond.

Transfer-RNA: the early adaptor

Naturwissenschaften

Transfer-RNA: an early gene?

Naturwissenschaften

Statistical geometry in sequence space: a method of quantitative comparative sequence analysis

How old is the genetic code? Statistical geometry of tRNA provides an answer

Science

Statistical Methods for Research Workers