Journal of Ultrastructure Research
Fine structure studies on the planarian, Dugesia: I. Nature of the “neoblast” and other cell types in noninjured worms1
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Serial block-face scanning electron microscopy of Schmidtea mediterranea
2023, Methods in Cell BiologyPlanarian stem cells specify fate yet retain potency during the cell cycle
2021, Cell Stem CellMitochondrial state determines functionally divergent stem cell population in planaria
2021, Stem Cell ReportsA lineage CLOUD for neoblasts
2019, Seminars in Cell and Developmental BiologyCitation Excerpt :Planarian neoblasts anarchically arise from an early cell population that express a unique set of embryo-enriched transcripts, distinct from the adult neoblasts [23]. Adult neoblasts are small roundish-to-ovoid cells ranging 5–10 μm, with high N/C ratio, abundant free ribosomes and few round mitochondria [24–26]. Bardeen and Baetjer showed in 1904 that neoblasts are required for the formation of the blastema [27], as planarians irradiated with 1750 rad failed to regenerate.
From worm to germ: Germ cell development and regeneration in planarians
2019, Current Topics in Developmental BiologyCitation Excerpt :The brain also connects to two ventral nerve cords, which run along the entire length of the animal and connect to a peripheral nerve plexus that innervates the planarian's body (Agata et al., 2009; Baguñà & Ballester, 1978; Chien & Koopowitz, 1977; Koopowitz & Chien, 1975). The planarian epidermis contains a single layer of epidermal cells overlaying a complex body wall musculature composed of layers of circular, diagonal, and longitudinal muscle fibers (Cebrià et al., 1996; Hay & Coward, 1975; Kobayashi, Kobayashi, Orii, Watanabe, & Agata, 2009; MacRae, 1965; Morita, 1965). The planarian digestive system consists of a highly branched intestine comprised of absorptive phagocytes that take up food particles and secretory goblet cells that produce digestive enzymes (Bowen, Ryder, & Thompson, 1974; Corrales & Gamo, 1986; Garcia-Corrales & Gamo, 1988; Ishii, 1965).
Evolutionary developmental biology (evo-devo) of cestodes
2017, Experimental ParasitologyCitation Excerpt :Many of these genes have been show by RNAi to have an important function in neoblast maintenance or differentiation, including orthologs of vasa and piwi (Reddien et al., 2005; Wagner et al., 2012). Furthermore, neoblasts have perinuclear ribonucleoprotein granules denominated “chromatoid bodies”, which are morphologically, molecularly and functionally similar to the germ granules present in the germ cells of many animals (Morita et al., 1969; Hay and Coward, 1975; Auladell et al., 1993; Yoshida-Kashikawa et al., 2007; Shibata et al., 2016). In cestodes, undifferentiated proliferating cells (equivalent to the planarian neoblasts) are usually denominated “germinative cells”.
- 1
Supported by U.S. Public Health Service Grant HD-00143 and National Science Foundation Grant GB-19630.
- 2
USPHS Special Postdoctoral fellow (GM-25351-01).