Effect of chronic administration of Ginkgo biloba extract or ginkgolide on the hypothalamic-pituitary-adrenal axis in the rat
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Cited by (56)
Pharmacologic treatments in preclinical tinnitus models with special focus on Ginkgo biloba leaf extract EGb 761®
2021, Molecular and Cellular NeuroscienceNeuroprotective effect of aspirin combined with ginkgolide injection on cerebral ischemic stroke rats and its effect on ERK12 signal pathway
2021, Saudi Journal of Biological SciencesCitation Excerpt :Aspirin is a non-steroidal anti-inflammatory medicine with broad spectrum pharmacological effects and multiple sites of action, which has been widely used to treat diseases (Larssonet al., 2006). Ginkgolide injection is a traditional Chinese medicine composed of effective components of Ginkgo biloba, which has the effects of promoting blood circulation, removing blood stasis, dredging channels and activating collaterals (Marcilhac et al., 1998; Moon et al., 2011; Nabavi et al., 2015; Feng et al., 2019). At present, the synergistic neuroprotective effect of aspirin and ginkgolide injection on cerebral ischemic stroke model in rats is still unclear.
Ginkgo biloba
2019, Medicinal Plants of South Asia: Novel Sources for Drug DiscoveryPharmacogenomic assessment of herbal drugs in affective disorders
2019, Biomedicine and PharmacotherapyCitation Excerpt :They are key regulators of cholesterol transport from outer to inner mitochondrial membrane [119,120]. Under conditions of stress, PBR mRNA expression and protein synthesis increases, thus increasing the amount of cholesterol available in mitochondria for glucocorticoid synthesis, which in turn leads to hypersecretion of corticosterone, worsening the pathological state [121]. In of the earliest studies done by Amri et al., phytoactive constituents from Ginkgo biloba leaves, EGb 761 and ginkgolide A or B, decreased mRNA expression of PBR on adrenocortical mitochondria without affecting the basal corticosteroid levels.
Current perspectives of tinnitus and its therapeutic options
2015, European Geriatric MedicineCitation Excerpt :Tinnitus is a serious problem with a relatively high prevalence, whose etiopathogenesis has not been unequivocally elucidated to date. A number of triggers have been suggested and a variety of therapeutic strategies have been developed; these, however, do not usually eliminate the problem completely but only make it less annoying [25,33–50]. Tinnitus can be a symptom of a serious disease, so we especially for newly created difficulties should not underestimate this symptom.