Increased expression of peripheral benzodiazepine receptors and diazepam binding inhibitor in human tumors sited in the liver
References (35)
- et al.
J. Biol. Chem.
(1986) - et al.
Biochemical Pharmacology
(1996) - et al.
Mo. Cell. Endocrinol.
(1992) - et al.
Life Sci.
(1991) Biochem. Biophys. Acta
(1995)- et al.
J. Biol. Chem.
(1990) - et al.
J. Biol. Chem.
(1991) - et al.
B. Regul. Pept.
(1994) - et al.
Life Sci.
(1987) - et al.
Blood
(1996)
Life Sci.
Regul. Pept.
Gastroenterology
Pharmacology
Annu. Rev. Neurosci.
Mol. Pharmacol.
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Endozepines and their receptors: Structure, functions and pathophysiological significance
2020, Pharmacology and TherapeuticsMetal complexes targeting the Translocator Protein 18 kDa (TSPO)
2017, Coordination Chemistry ReviewsCitation Excerpt :Moreover, heterogeneous cell type-specific TSPO expression has been found in several tissues [7,8] and subcellular localization studies have demonstrated that TSPO is localized primarily on the outer mitochondrial membrane [7,9,10] but also in Golgi apparatus, lysosomes and peroxisomes [11], and on plasma membrane [12]. Interestingly, TSPO is overexpressed in a variety of tumors (e.g., certain brain tumors, ovarian cancer, liver tumors, breast carcinoma, colorectal cancer, etc.) and its expression appears to be related to the degree of tumor malignancy [13–16]. In addition, TSPO is overexpressed on activated microglial cells localized in lesioned brain areas of patients with neurodegenerative or neuroinflammatory diseases like Alzheimer’s disease, Huntington’s disease, and multiple sclerosis [17,18].
Long-chain acyl-CoA esters in metabolism and signaling: Role of acyl-CoA binding proteins
2015, Progress in Lipid ResearchCitation Excerpt :A number of external cues have been shown to increase ACBP expression in selected areas of rat brain, including acute stress [187,188], psychological but not physical stress [189], alcohol intake [190–193], nicotine [194–196], diazepam [197,198], continuous treatment with morphine [199], butanol [200] and N-methyl-d-aspartate (NMDA) [201]. Moreover, ACBP levels are also increased in liver, ovarian and brain tumors [202–205] and extraordinarily found in urine after chemotherapy of gall bladder cancer patients [206]. The expression level of the mammalian ACBP is also affected by feeding status.
Secretome protein signature of human gastrointestinal stromal tumor cells
2015, Experimental Cell ResearchCitation Excerpt :By comparing the stimulated groups with the control group we revealed subsets of proteins being significantly released upon stimulation. In fact, the majority of the significantly elevated secretory proteins in the thapsigargin group (Table 2) have already been acknowledged in other tumor types, for example; trypsin and PEA-15 in colon cancers [54,55], RNA-binding protein FUS (fused in sarcoma) in myxoid liposarcoma [56], calpain small subunit 1, insulin-like growth factor-binding protein 7, and Acyl-CoA-binding protein in hepatocellular carcinomas [57–59], proteasome subunit alpha type-3 in esophageal cancer [60], inter-alpha-trypsin inhibitor heavy chain H4, fibulin-1, and protein CDV3 homolog in breast cancer [61–63], Apo A-I in ovarian cancer [64], Peroxiredoxin-5 in human lung carcinoma cells [65], glutathione S-transferase Mu 3 in gastric cancer [66], and neutral alpha-glucosidase AB in head and neck cancer [67]. It is also noteworthy that blocking the mutated c-KIT protein with imatinib radically changed the protein release pattern (Tables 2 and 4, Fig. 2).