Relationships in men of sex hormones, insulin, adiposity, and risk factors for myocardial infarction☆
Section snippets
Patients and methods
Eighty adult males recruited from a multiethnic community through advertisements were studied. Inclusion required that the subject be healthy, not regularly participating in vigorous physical activity training programs, not having gained or lost > 10% of body weight within the past year, not having a history of drug or alcohol abuse, and not taking medications known to influence serum lipid levels or body composition. The health of the subjects was determined by history, physical examination,
Results
The means, SEMs, and ranges of the variables measured in the 80 men are shown in Table 1.
Table 2 shows the Pearson correlation coefficients of measures of adiposity with risk factors for MI, insulin, and sex hormones. Because W and WHR correlated so similarly with these variables and with each other (r = .86, P < .001), the data on W are not shown. Although VAT correlated with BMI (r = .65), TAT (r = .71), SCAT (r = .69), WHR (r = .78), and W (r = .81), all P < .001, VAT correlated more
Discussion
Sex hormones, insulin, and obesity have all been reported to correlate with risk factors for MI in men.11, 14, 15 Although a correlation does not by itself mean a cause and effect relationship or, if so, indicate which is the cause, each of these 3 variables has been suggested as the link that underlies the risk factors for MI to form the constellation.1, 2, 3, 4, 6, 7 In the present study, testosterone, FT, estradiol, estrone, insulin, 6 adiposity variables, and risk factors for MI were
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2014, Journal of Sexual MedicineCitation Excerpt :D98 circulating E2 levels (Rho 0.43, P = 0.03) and percent change in E2 from baseline (Rho 0.44, P = 0.02) correlated with GDR2 while circulating DHT levels did not. Elevated E2/T ratio has been associated with higher insulin levels in apparently healthy men [29], as well as the metabolic syndrome in men with newly diagnosed impaired glucose tolerance or diabetes [30]. The E2/T ratio did not change significantly in the placebo or T/DHT/E2 groups after treatment.
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Supported in part by National Institutes of Health Grant No. DK PO1-42618.