Fasting and daylong triglycerides in obesity with and without type 2 diabetes
Section snippets
Subjects
Data were analyzed from 142 subjects who participated in a study aimed to evaluate daylong TG changes in an out-of-hospital situation. Inclusion criteria were age 35 to 65 years and fasting cholesterol < 7 mmol/L. Type 2 diabetic subjects were included from the department of Internal Medicine from the University Medical Center Utrecht and fulfilled the criteria as described by the American Diabetes Association.27 Exclusion criteria for diabetic patients were glycosylated hemoglobin (HbA1c) >
General characteristics
Nine-teen type 2 diabetics, 45 obese nondiabetics and 78 lean subjects were included in this study. Group-wise general characteristics of the participants are listed in Table 1. Fasting plasma TG was higher in diabetics and obese nondiabetics than in lean subjects. Obese nondiabetics had elevated HOMA compared with lean subjects. Body composition and fasting plasma lipids and apolipoproteins were comparable between diabetics and obese nondiabetics. Three diabetic subjects were on insulin
Discussion
Metabolic ward studies have shown that both type 2 diabetics and obese nondiabetics are characterized by postprandial hyperlipidemia compared with healthy subjects.17, 18, 19, 20 However, direct comparisons between groups matched for BMI, with and without diabetes, are scarce. In our study, daylong triglyceridemia was similarly disturbed in diabetic and nondiabetic obese subjects compared with lean controls, suggesting that obesity largely determines postprandial lipemia in both disorders,
Acknowledgements
Roche Diagnostics (Mannheim, Germany) is greatly acknowledged for providing the Accutrend GCT meters with accessories.
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