Impaired glucose handling in active rheumatoid arthritis: Relationship to peripheral insulin resistance☆
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2016, Revista Brasileira de ReumatologiaCitation Excerpt :Other studies also showed that the continuous use of corticosteroids is an independent predictor of IR and MS in patients with RA,13,28 while other authors have found no such association.18 It seems that, thanks to their systemic anti-inflammatory effect, short-term glucocorticoids could improve IR,40,41 but the long-term side effects (dyslipidemia, hyperglycemia, hypertension, IR and abdominal obesity) could collectively contribute to an increase of insulin resistance and the development of MS and atherosclerosis. An American study with 131 patients and 121 controls without RA showed MS rates of 36% in RA and 27% in controls, with no statistically significant difference.20
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Supported by the Medical Faculty of the University of Uppsala and the Swedish Medical Research Council.