Original researchCondyloma in pregnancy is strongly predictive of Juvenile-Onset recurrent respiratory papillomatosis☆
Section snippets
Materials and methods
Between 1974 and 1993, the Danish Medical Birth Registry recorded 1,206,213 births in Denmark. We identified 3033 women who had genital warts during pregnancy by linking the data in the Danish National Hospital Registry with those in the Danish Medical Birth Registry. A representative sample (n = 7902) of all births was selected by a simple random sample from the Danish Medical Birth Registry database to serve as a comparison group for the women with genital warts. We identified 57 cases of
Results
Of the 1.2 million live births in Denmark during the study period, we identified 57 respiratory papillomatosis cases, corresponding to an overall risk of 4.7 per 100,000 births and an overall rate of 3.5 per 1,000,000 person-years. There were no statistically significant differences (P < .05) of selected characteristics between the 3033 newborns identified from the Danish national registries with a maternal history of genital warts and the 7902 randomly selected sample of births without such a
Discussion
The valuable resource of the Danish national registries allowed for the longitudinal evaluation of maternal and infant characteristics associated with respiratory papillomatosis. Fifty-seven respiratory papillomatosis cases occurring during a follow-up were identified by medical record review, corresponding to an overall rate of 3.5 per 1,000,000 person-years, which is similar to the rate reported by Lindeberg and Elbrond.5 A maternal history of genital warts in pregnancy was identified as the
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This research was supported in part by a National Cancer Institute grant (RO3 CA86170-01).