Original ArticlesDiet and sex-hormone binding globulin, dysmenorrhea, and premenstrual symptoms
Section snippets
Materials and methods
The study was approved by the institutional review board and the Department of Obstetrics and Gynecology of the Georgetown University. Volunteers were recruited through newspaper advertisements and notices mailed to gynecologists in the Washington, DC, area. All participants gave written informed consent before enrollment. Participants were to be at least 18 years of age, with menstrual periods accompanied consistently by moderate to severe abdominal pain causing significant distress or
Results
Fifty-one volunteers met the criteria for participation. Their demographic characteristics are listed in Table 1. Twelve volunteers failed to complete the study due to menopause (1), pregnancy (1), repeatedly missing group meetings (2), noncompliance with the intervention diet (2), extended overseas travel (1), death in the family (1), major financial problems (1), spouse objections to the diet (1), scheduling difficulties (1), and unknown reasons (1). In addition, six participants were
Discussion
In women with moderate to severe dysmenorrhea, a low-fat, vegetarian diet was associated with a significant increase in mean serum sex-hormone binding globulin concentration and reductions in mean body weight and BMI as well as significant reductions in menstrual pain duration, pain intensity, and duration of premenstrual symptoms related to concentration, behavioral change, and water retention.
There are several ways that diet might affect PG synthesis. Diet influences sex hormone concentration
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