Elsevier

Optics Communications

Volume 188, Issues 5–6, 15 February 2001, Pages 267-273
Optics Communications

Endoscope-compatible confocal microscope using a gradient index-lens system

https://doi.org/10.1016/S0030-4018(00)01164-0Get rights and content

Abstract

We present an endoscope-compatible confocal laser scanning microscope (CLSM) for medical imaging. A gradient index (GRIN)-lens system projects a magnified image on the distal end of a fiber-optic imaging bundle, which transfers the image to a CLSM situated at the proximal end. As the maximum diameter of the distal optics is 1 mm, application through the accessory channel of a conventional endoscope is possible. A lateral resolution of 3.1 μm and an axial resolution of 16.6 μm is achieved. Confocal images of colonic tissue stained with a fluorescent marker are shown.

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Acknowledgements

This research was supported in part by the BMBF grant 13N6943. We thank B. Bültmann and U. Vogel for providing access to the confocal microscope (Zeiss LSM 410).

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