Cyanobacterium-catalyzed asymmetric reduction of ketones
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Cited by (79)
Enhancing cofactor regeneration of cyanobacteria for the light-powered synthesis of chiral alcohols
2022, Bioorganic ChemistryCitation Excerpt :PCC 6803 is the first photosynthetic organisms to complete whole-genome sequencing, which provides a clear genetic background for its metabolic engineering and synthetic biology manipulation [1]. Although the biotransformation of cyanobacteria as a whole-cell catalyst have reported [12,28,29,46], the influence factor of its unique physiological characteristics on the catalytic performance is unclear, which impedes the further development for biocatalysis. In particular, it is necessary to elucidate the effect of photosynthetic regeneration of the reductive cofactor NADPH on catalytic properties of cyanobacteria for asymmetric synthesis of chiral compounds in order to develop an efficient whole-cell catalyst for industrial biocatalysis.
Biocatalysis in Green and Blue: Cyanobacteria
2021, Trends in BiotechnologyThe effect of CO<inf>2</inf> in enhancing photosynthetic cofactor recycling for alcohol dehydrogenase mediated chiral synthesis in cyanobacteria
2019, Journal of BiotechnologyCitation Excerpt :Cyanobacteria are photoautotrophs capable of harvesting light energy and sequestering CO2, thereby maintaining the redox balance in the cell by recycling NADPH and ATP, via the photosystem (PS) and Calvin cycle (Alagesan et al., 2016, 2013; Hendry et al., 2016; Yamanaka et al., 2011). This light driven synthesis of NADPH has been demonstrated as an efficient system for cofactor recycling during biotransformation using both native and recombinant cyanobacteria (Köninger et al., 2016; Nakamura et al., 2000; Nakamura and Yamanaka, 2002a). While the effect of CO2 in modulating product enantioselectivity has been observed in the conversion of acetophenone in cultures of Nicotiana tabacum, it did not affect the conversion efficiency (Kojima et al., 2009).
Using algae cells to drive cofactor regeneration and asymmetric reduction for the synthesis of chiral chemicals
2018, Algal ResearchCitation Excerpt :Nakamura et al. found that Synechococcus sp. PCC7942 had good catalytic activities on perfluoroacetophenone [21], its conversion efficiency was about 95% and e.e. was >99%. They also found the catalytic efficiency of Synechococcus elongates PCC7942 on α,α‑difluoroacetophenone was higher (99%) and e.e. relatively lower (70%) [29].