Case StudyEpstein-barr virus-associated Hodgkin's lymphoma and legionella pneumophila infection complicating treatment of juvenile rheumatoid arthritis with methotrexate and cyclosporine A
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Cited by (29)
Pharmacology and Drug Therapy: Nonbiologic Therapies
2015, Textbook of Pediatric RheumatologyCytostatic and cytotoxic drugs
2014, Side Effects of Drugs AnnualCitation Excerpt :For example, in 17 patients with juvenile idiopathic arthritis seven had adverse reactions: gastrointestinal discomfort (n = 4), a rise in aminotransferases (1), and a rise in serum creatinine concentration (1) [208c]. However, in one series of 19 patients with severe active rheumatoid arthritis three withdrew because of adverse events [209c] and there have been reports of infections in patients who were given the combination, including disseminated cryptococcal infection [210A], Pneumocystis jirovecii pneumonia [211A], and fatal Epstein–Barr virus-associated Hodgkin's lymphoma and Legionella pneumophila infection in a child [212A]. In one case Epstein–Barr virus-associated lymphoma regressed when methotrexate and ciclosporin were withdrawn [213A].
Pharmacology and drug therapy
2011, Textbook of Pediatric RheumatologyEuropean evidence-based Consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease
2009, Journal of Crohn's and ColitisCitation Excerpt :It is possible that ganciclovir is more potent than aciclovir for EBV infection and may help prevent lymphoproliferative disorders, but further data are necessary.148 A higher rate of lymphoma has been reported in patients with IBD, especially if treated with immunomodulators, compared to the general population.151,152–169 In transplant recipients, a viral load of > 1000 copies of EBV per 500 ng DNA from PBMCs may be a marker for an increased risk of EBV-associated lymphoproliferative disorders.143
Problem pathogens: paediatric legionellosis-implications for improved diagnosis
2006, Lancet Infectious DiseasesCitation Excerpt :We suggest an approach that might uncover occult cases of Legionnaires' disease in children to allow earlier treatment and, possibly, prevention. We identified 76 cases of legionella infection in children that fulfilled our inclusion criteria.1–56 Diagnosis was made with legionella culture methodology in 45 (59%) of these cases; culture was the only diagnostic method that was positive in 23 (30%) cases.
Pharmacology and drug therapy
2005, Textbook of Pediatric Rheumatology