Mucinous islet cell (amphicrine) carcinoma of the pancreas associated with watery diarheaand hypokalemia syndrome*
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Cited by (34)
Periampullary neuroendocrine tumor with large intracellular mucin globules, an amphicrine tumor?
2018, Human Pathology: Case ReportsCitation Excerpt :However, it has been reported that the neuroendocrine cells may show aberrant mucin production, indicating neuroendocrine tumor with different differentiation. At the same time, the neuroendocrine tumor with extra and intracellular mucin production has been called amphicrine carcinoma with these exocrine and endocrine markers co-expressed by the same tumor cells [6]. To what extent of mucin production should the tumor have to be considered as amphicrine is a question for discussion and currently there are no established criteria yet.
Malignant-functioning neuroendocrine tumors of the pancreas: A survival analysis
2016, Surgery (United States)Amphicrine (mixed adenoneuroendocrine carcinoma) of the duodenum and coexistent metastatic well differentiated neuroendocrine tumour
2014, Diagnostic HistopathologyCitation Excerpt :The case presented herein falls into the category of amphicrine carcinoma. Amphicrine carcinomas are extremely rare, however they have been described in various organs, such as skin,3 sinonasal cavities,5 larynx,6 lung,7,8 gastrointestinal tract,9–12 pancreas,13 thyroid,14,15 breast,16 middle ear,17 uterine cervix,18 vulva19 and prostate.20 Mandoky reported 16 cases of amphicrine carcinomas from various organs including stomach, duodenum, ileum and cecum.20
A case of hyperfunctioning pancreatic mixed adenoneuroendocrine carcinoma (MANEC) arising from ectopic pancreatic tissue in the liver
2014, Radiology Case ReportsCitation Excerpt :While MANECs contain neuroendocrine cells, the vast majority of these tumors are nonhyperfunctioning or nonsyndromic, suggesting that these cells remain in a primitive state or produce immature hormones (1). That being said, there are case reports of hyperfunctioning MANECs presenting with symptoms of watery diarrhea, similar to this case, as well as Zollinger-Ellison Syndrome (6, 7). A subset of pure ACC develops a lipase hypersecretion syndrome characterized by skin rashes, arthralgias, and fat necrosis.
Synchronous epithelial and neuroendocrine cancers of the pancreas: Case series of a rare occurrence
2011, Clinical Colorectal CancerCitation Excerpt :Molecular studies of mixed NE and epithelial tumors from colon and gastric case series have concluded that both histologies are derived from the same cell of origin, ie, a pluripotent epithelial stem cell or an adenocarcinoma precursor cell.5,22 Our cases add to scant literature of synchronous PNET and adenocarcinoma in the pancreas.23–36 Mixed ductal and endocrine tumors of the pancreas are defined histologically according to a WHO classification in which the malignant epithelial ductal element of the primary tumor is mixed with NE cells and similarly in the metastases in which the NE cells make up at least 1 third to half of the tumor tissue.8,37
Mixed endocrine tumors
2005, Annales de Pathologie
- *
Supported by the Caduceus Foundation of New York.
- 1
from the Department of Pathology,The University of Texas M. D. Anderson Hospital and Tumor Institute at Houston; and the Department of Pathology, Diagnostic Clinic of Houston.