Original contributionHuman herpesvirus-8-associated body cavity-based lymphoma in human immunodeficiency virus-infected patients: A unique B-cell neoplasm
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Lymphoid Lesions of the Lung
2018, Pulmonary Pathology: A Volume in the Series: Foundations in Diagnostic PathologyExtracavity primary effusion lymphoma presenting in a lymph node without lymphomatous effusions
2015, Human Pathology: Case ReportsCitation Excerpt :It can also occur as a nodal extracavitary lymphoma, as in the current case [9,16]. Although EPEL develops primarily, although not exclusively, in patients with AIDS or severe immunodeficiency [2,8], the diagnosis of EPEL warranted HIV testing, which was positive in this case. PEL has an extremely unfavorable prognosis with a median overall survival time of less than six months [17].
Lymphoproliferative disorder in pleural effusion in a subject with past asbestos exposure
2015, Respiratory Medicine Case ReportsCitation Excerpt :The 2001 World Health Organization classification defines PEL as a disease entity representing a part of diffuse large B-cell lymphoma [1]. PEL is commonly associated with HHV8 infection [2]; however, PEL-like disease processes have recently been reported in HHV8-negative patients. Those cases are considered a rare disease entity called HHV8-unrelated PEL-like lymphoma [3].
Complete response to EPOCH in a patient with HIV and extracavitary primary effusion lymphoma involving the colon: A case report and review of literature
2012, Clinical Lymphoma, Myeloma and LeukemiaCitation Excerpt :Karcher et al described the distinctive characteristics of PEL, including the initial presentation as a lymphomatous effusion in the absence of a contiguous tumor mass.1 Its epidemiologic features are similar to Kaposi's sarcoma (ie., occurring primarily in men, most of whom are HIV+ with homosexuality as a risk factor) 1,7 Morphologically, PEL bridges immunoblastic anaplastic features and displays a degree of plasma cell differentiation as shown by immunohistochemical positivity for CD138/syndecan-1, a plasma cell–associated antigen.8,10 Distinguishing PEL from other NHLs involving body cavities initially involves clinical and basic morphologic assessment and is enhanced by immunocytochemical and/or flow cytometric demonstration of positivity for HHV-8 and negativity for most B-cell–associated antigens.9
Update on pulmonary and pleural lymphoproliferative disorders
2008, Diagnostic HistopathologyCitation Excerpt :PEL is considered a post-germinal centre B-cell lymphoma with plasmacytic differentiation which often develops in the setting of immunosuppression due to the oncogenic effects of latent infection with HHV-8.166,167 Co-infection with EBV occurs in about 80% of cases and likely contributes to neoplastic transformation.159,160,176,183 More recently, PEL has been recognized as part of the spectrum of diffuse large B-cell lymphomas with plasmablastic differentiation.189
Lymphoid Lesions of the Lung
2008, Pulmonary Pathology: a Volume in the Series Foundations in Diagnostic Pathology