Original contributionAssessment of proliferative activity in breast cancer: MIB-1 immunohistochemistry versus mitotic figure count☆
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Cited by (45)
Prognostic significance of predominant histologic pattern and nuclear grade in resected adenocarcinoma of the lung: Potential parameters for a grading system
2013, Journal of Thoracic OncologyCitation Excerpt :Using the mitotic rate as a prognostic marker has the advantage of easy introduction into routine histopathologic practice, as it does not require specialist skills or equipment. Also, scoring the number of mitotic Fs has previously been shown to have an adequate interobserver agreement in other carcinoma types, such as the grading of breast carcinoma.24 Nuclear diameter on its own was not found to be a significant part of a nuclear grading system in this study, which contradicts studies which did find a significant correlation for cytonuclear structure,25,26 but concurs with a study by Kadota et al.18 in which the authors graded all aspects of tumor nuclear characteristics, including nuclear diameter, but found only mitotic count to provide useful prognostic information.
Ki-67 expression in axillary lymph node metastases in breast cancer is prognostically significant
2013, Human PathologyCitation Excerpt :It may serve as a biomarker for the degree of growth of a given cell population. Several studies have documented the prognostic significance of data obtained with this antibody in breast cancer and its positive relationship with histologic grade, tumor size, mitotic activity, hormonal and Her-2 status [5,8,11,14,16–20]. We have reported a direct correlation between Ki-67 expression in breast cancer cells and prognosis for disease-free survival and overall survival [18,19].
Prognostic and predictive role of ESR1 status for postmenopausal patients with endocrine-responsive early breast cancer in the Danish cohort of the BIG 1-98 trial
2012, Annals of OncologyCitation Excerpt :The prognostic implication of proliferation and its relation to classical prognostic factors has been demonstrated clearly in a meta-analysis of gene expression profiles in breast cancer [6]. The Ki-67 labeling index is an established indicator of proliferation [7, 8] and also appears to differentiate luminal A from luminal B subtypes in ER-positive and HER2-negative breast cancer [9]. The implementation of gene expression profiles in clinical practice is complicated by the requirement for either freshly frozen tumor tissue or otherwise complicated extraction processes.
Multivariate prognostic evaluation of the mitotic activity index and fibrotic focus in node-negative invasive breast cancers
2005, European Journal of CancerUpregulation of phospholipase D expression and activation in ventricular pressure-overload hypertrophy
2005, Journal of Pharmacological Sciences
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Supported in part by the Robert Müller Foundation, Mainz, Germany.