Rabies Virus Epitopic Variation: Use in Ecologic Studies

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People living in the industrialized societies of Europe and North America are less at risk from dying of rabies than of being struck by lightning.. Before dismissing rabies as a trivial public health problem, however, it must be noted that the low incidence of human rabies is not the consequence of disease eradication; rather it is the result of control programs comprising massive preexposure and postexposure prophylaxis and dog immunization. Recent advances in vaccine technology have suggested new avenues of rabies control that, in addition to preventing human infection, may also actually eradicate the disease from its animal reservoir, thus eliminating the need for human and domestic animal prophylaxis. Oral vaccination of red foxes by field baiting has dramatically reduced rabies in some European countries and may have eliminated it from some areas.

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