ArticlesIncreased S(−)-Apomorphine–Induced Vacuous Chewing and Attenuated Effect of Chronic Haloperidol Treatment in Streptozotocin-Induced Diabetic Rat
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Method
Male Sprague–Dawley rats (Zivic Miller Laboratories, Pittsburgh, PA), weighing 200–250 g on arrival in the laboratory, were used. The rats were housed in groups of five or six in standard floor net cages in a light- and temperature-controlled room and had free access to food and water.
Animals were rendered diabetic according to an established protocol [2]. STZ (65 mg/kg, in 0.01 M citrate buffer, pH 4.5, 1 ml/kg; Sigma Chemical Co., St. Louis, MO) was injected into the lateral tail vein. An
Results
STZ-treated rats showed a loss of weight gain which continued throughout the study period (Table 1). Blood glucose levels in STZ-induced DM rats 1 week after STZ treatment (STZ–HPD and STZ–vehicle groups) were elevated about fourfold compared with non-DM rats (vehicle–HPD and vehicle–vehicle groups) (Table 2). All rats assigned to the DM groups (STZ–HPD and STZ–vehicle) were found to be hyperglycemic (blood glucose > 332 mg/dl). Diabetes was also verified by glucosuria (Chemstrip; Boehringer
Discussion
The present study provides the first evidence for enhancement of S(−)-apomorphine–induced VCMs in STZ-induced DM rats. Moreover, the results confirm the previous finding of an increased incidence of apomorphine-induced VCMs following chronic neuroleptic treatment [31]. The present findings also demonstrated a lower incidence of S(−)-apomorphine–induced VCMs in rats receiving both HPD and STZ relative to animals receiving HPD alone.
The present study used 250 μg/kg S(−)-apomorphine, a dose which
Acknowledgements
The authors are grateful to H. A. Johnston for research assistance and L. Mason for secretarial assistance. This research was supported in part by the National Alliance for Research on Schizophrenia and Depression.
References (32)
- et al.
D1 and D2 receptor modulation in rat striatum and nucleus accumbens after subchronic and chronic haloperidol treatment
Brain Res.
(1992) - et al.
Expression of stereotyped behaviour requires stimulation of nigral D1 dopamine receptors
Brain Res.
(1995) - et al.
Hydroxy radical formation in diabetic rats induced by streptozotocin
Life Sci.
(1995) Dopaminergic activity is reduced in diabetic rats
Neurosci. Lett.
(1984)- et al.
Suppression of haloperidol-induced oral dyskinesias in rats by vigabatrin
Pharmacol. Biochem. Behav.
(1995) - et al.
Behavioral supersensitivity to apomorphine following chronic treatment with drugs which interfere with the synaptic function of catecholamine
Neuropharmacology
(1974) - et al.
Emergence of apomorphine-induced “vacuous chewing” during 6 months continuous treatment with fluphenazine decanoate
Eur. J. Pharmacol.
(1980) - et al.
Altered behavior and neurochemistry during short-term insulin withdrawal in streptozotocin-induced diabetic rats
Diabetes
(1991) - et al.
Regionally specific alterations in mesotelencephalic dopamine synthesis in diabetic ratsAssociation with precursor tyrosine
J. Neural Transm.
(1989) - et al.
Alterations in physiological functions and in brain monoamine content in streptozotocin-diabetic rats
Diabetes
(1986)
Effects of chronic trifluoperazine administration and subsequent withdrawal on the production and persistence of perioral behaviours in two rat strains
Psychopharmacology
Repeated treatment with (−)-sulpiride plus a low dose of SCH 23390 displays wider neuroleptic activity without inducing dopaminergic supersensitivity
Psychopharmacology
Effects of long-term haloperidol treatment on the responsiveness of accumbens neurons to cholecystokinin and dopamineElectrophysiological and radioligand binding studies in the rat
J. Neurosci.
The prevalence of tardive dyskinesia in neuroleptic-treated diabetes
Arch. Gen. Psychiatry
Vitamine E attenuates the development for haloperidol-induced dopaminergic hypersensitivity in ratsPossible implications for tardive dyskinesia
J. Neural. Transm. Gen. Sect.
Oral dyskinesias in rats following brain lesions and neuroleptic drug administration
Psychopharmacology
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