ArticlesAttenuation of Alcohol Consumption by a Novel Nontoxic Ibogaine Analogue (18-Methoxycoronaridine) in Alcohol-Preferring Rats
Section snippets
Animals
Eight adult male alcohol-preferring rats were used for this project. Rats were obtained from a colony of selectively bred alcohol-preferring rats established at the Indiana University. When given a choice between water and a solution of 10% alcohol, these rats show a high preference for alcohol 34, 35, 36. This strain has been used extensively in the field of alcohol research 6, 19, 21, 31, 32, 34, 35, 36.
Animals were housed individually in suspended stainless steel wire-mesh cages (26 × 34 ×
Results
When given free access to alcohol, water and food, alcohol-preferring rats consumed an average of 81.6 ± 5.7 ml/kg (6.4 ± 0.4 g/kg) alcohol, 6.4 ± 0.4 ml/kg water and 54 ± 3 g/kg food per day. Compared with control vehicle, a single injection of 5, 20 or 40 mg/kg 18-MC significantly reduced alcohol intake in a dose-dependent fashion [F(3, 18) = 10.57, p < 0.01] (Fig. 1A). The proportion of alcohol intake to total fluid intake, which has been used as a reliable index of alcohol preference in
Discussion
The present data show, for the first time, that 18-MC, a novel nontoxic ibogaine analogue, when injected acutely can significantly reduce alcohol intake and alcohol preference in a dose-dependent manner in a strain of alcohol-preferring rats. The specificity of this compound for suppressing alcohol intake is highlighted by the fact that, at doses that significantly suppressed alcohol intake and preference, there was a commensurate increase in water intake. Further, food intake was not
Acknowledgements
We thank Dr. T.-K. Li and colleagues at the Indiana Alcohol Research Center (P50-AA07611) for providing the alcohol-preferring rats. This study was supported in part by grants DA 03817 (S. D. G.) and CA 12010 (M. E. K.) and a grant from the Skipper Bowles Center for Alcohol Studies (A. H. R.).
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