Early childhood respiratory symptoms and the subsequent diagnosis of asthma☆,☆☆,★,★★
Section snippets
METHODS
Subjects are participants in the Tucson Epidemiologic Study of Airways Obstructive Disease, a longitudinal study of a representative sample of white, non-Mexican-American households in Tucson, Arizona. Methods of selection of the overall population sample have been reported in detail.6 Briefly, the sample consists of a random cluster sample of households in the city in 1971 and 1972, stratified on the basis of age of head of household and socioeconomic status. Over the years, we have continued
RESULTS
In Table II we have shown the prevalence of asthma in subjects between ages 1 and 11 years, grouped by their lower respiratory tract symptoms before the age of 1 year. We have included the 38 subjects who were diagnosed with asthma between the ages of 1 and 5 years, but we did exclude the one subject who was diagnosed before the age of 1 year. No single symptom, such as wheeze even without colds, in two-way comparisons with children without that symptom, significantly increased the risk of a
DISCUSSION
This report is one of several prospective studies that we have published on Tucson subjects who were subsequently diagnosed with asthma.9, 10, 11 In all of these reports, which separately examined subjects aged 10 to 19, 20 to 40, and over 60 years, asthma was frequently preceded by lower respiratory tract symptoms, sometimes for years. Among subjects who were diagnosed with asthma after age 60, for example, one third reported respiratory symptoms before age 16.11 Similarly, here we report that
Acknowledgements
We thank the subjects and their parents for their continuing commitment to the Tucson Study.
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Recent Advances in Severe Asthma: From Phenotypes to Personalized Medicine
2020, ChestCitation Excerpt :Childhood-onset and adult-onset asthma differ regarding sex ratios, exacerbation triggers, comorbidities and severity, and genetics, suggesting that these may have nonoverlapping features.23-25 In childhood-onset asthma, older age of diagnosis (> 15 years of age), sensitization as measured by elevated serum IgE levels, low lung function, and increased airway hyperresponsiveness have been associated with more severe or persistent asthma.26,27 Overall, adult-onset asthma is more severe, has a lower remission rate, and is not as frequently associated with allergy when compared with childhood-onset asthma.28,29
Contrasting associations of maternal smoking and pre-pregnancy BMI with wheeze and eczema in children
2018, Science of the Total EnvironmentCitation Excerpt :The majority of wheeze in the first 4–5 years of life is transient and could be due to post-infectious wheeze and narrow airways; however, this wheeze phenotype does not increase risk of asthma in later life. In a substantial minority of infant, there are IgE-associated wheeze episodes with higher prevalence after first 5 years of life, potentially related to a predisposition to asthma in later life (Martinez et al., 1995; Dodge et al., 1996). In our cohort, the prevalence of wheeze in children at 7 years was significantly higher in those whose mother had high pre-pregnancy BMI, which is also consistent with some recent reports (Mitchell et al., 2012; Leermakers et al., 2013; Pike et al., 2013; Harpsøe et al., 2013; Ekström et al., 2015; Dumas et al., 2016); however, unlike wheeze, the protective impact of high maternal pre-pregnancy BMI on eczema reached significance only at the age of 7 years.
Statistical associations between housing quality and health among Finnish households with children - Results from two (repeated) national surveys
2017, Science of the Total EnvironmentCitation Excerpt :Decline in one's health almost always shows first as an appearance of a symptom or symptoms and potentially later leads to a diagnosed illness (1).
Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjunctivitis, and eczema in children aged 6-7 years: analysis from Phase Three of the ISAAC programme
2008, The LancetCitation Excerpt :Four, similar to the findings of intrauterine exposure to paracetamol, our results suggest that exposure preceded the response. This interpretation is based on the fact that wheezing in the first year of life is often self-limiting and not a reliable predictor of asthma in later childhood.48–51 Finally, there is a temporal association between the worldwide trends towards increasing paracetamol use in childhood over the past 50 years21–24 and the increase in prevalence of childhood asthma in many countries during this period.1,2
Bronchial asthma evolution in children within 3 years from the diagnosis
2022, Meditsinskiy SovetIsolated night cough in children: How does it differ from wheeze?
2020, ERJ Open Research
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From the Respiratory Sciences Center, University of Arizona College of Medicine, Tucson.
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Supported by a National Heart, Lung, and Blood Institute Specialized Center of Research grant (HL-14135).
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Reprint requests: Russell Dodge, MD, Respiratory Sciences Center, Tucson, AZ 85724.
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