Nasal challenge with diesel exhaust particles can induce sensitization to a neoallergen in the human mucosa☆,☆☆,★
Section snippets
Subjects
Twenty-five healthy nonsmoking volunteers (11 men and 14 women), ranging in age from 21 to 55 years, were recruited in Los Angeles, California. Atopic subjects were chosen as individuals who might, under appropriate circumstances, mount an IgE response to a foreign protein when exposed through the airway. All subjects had a positive skin prick test response to at least one aeroallergen but not to dust mite allergens. Additionally, all subjects had a history of prior seasonal airway allergies
Mucosal Ig response to KLH alone
Initially it was necessary to establish an intranasal KLH immunization regimen that would elicit a local humoral immune response. Fig 1 shows the mucosal antibody response to KLH in 10 atopic subjects after 3 intranasal administrations with the antigen alone.
DISCUSSION
DEPs, as environmental pollutants, have become the focus of intense investigation as a model to elucidate the interaction between fossil fuel combustion products, the immune response, and disease outcomes.1, 12, 13 Studies in animal and human models have indicated that DEPs have mucosal adjuvant properties at the molecular and cellular level. In particular, the ability of DEPs to exacerbate allergic inflammation and augment production of allergic antibody has been demonstrated both in animal
Acknowledgements
We thank Dr Shigeru Takafuji (Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Tokyo, Japan) and Dr Hiroshi Takenaka (Department of Otorhinolaryngology, Kyoto Prefectural University of Medicine, Kyoto, Japan) for their kind gifts of diesel exhaust particles.
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Supported by the UCLA Asthma, Allergy and Immunologic Disease Center (AI-34567 funded by the National Institute of Allergy and Infectious Diseases and the National Institutes of Environmental Health Sciences), USPHS Grant AI-15251.
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Reprint requests: David Diaz-Sanchez, PhD, Division of Clinical Immunology/Allergy, Dept. of Medicine, 52-175 Center for Health Sciences, UCLA School of Medicine, Los Angeles, CA 90095-1680.
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