Cell
ArticleActivation of a low specific activity form of DNA polymerase α by inositol-1,4-bisphosphate
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Inositol polyphosphate 1-phosphatase is a novel antihypertrophic factor
2002, Journal of Biological ChemistryCitation Excerpt :In the case of Ins(1,4)P2, a role in cellular growth responses was reported in studies where exogenously expressed INPP localized to the nucleus and reduced DNA synthesis (46). Furthermore, Ins(1,4)P2 itself has been shown to activate DNA polymerase-α (47). However, given that postnatal cardiomyocytes are terminally differentiated and do not undergo substantial cell division, such effects on DNA synthesis are unlikely to be involved in the antihypertrophic action of INPP demonstrated in these experiments.
C-Fos is surface active and interacts differentially with phospholipid monolayers
2001, Biochemical and Biophysical Research CommunicationsNuclear domains involved in inositol lipid signal transduction
2000, Advances in Enzyme RegulationCitation Excerpt :The potential second messengers are not only the hydrolytic products of PI(4,5)P2, DAG and I(1,4,5)P3. Indeed, PI(1,4)P2 acts as second messenger for activating DNA polymerase α in cycling cells[94]. In previous paragraphs we reported evidence that PI(3,4,5)P3 and PI(3,4)P2 are directly involved as second messengers in multiple responses, as well as PI(4,5)P2.
Ca<sup>2+</sup>-activated but not G protein-mediated inositol phosphate responses in rat neonatal cardiomyocytes involve inositol 1,4,5-trisphosphate generation
2000, Journal of Biological ChemistryCitation Excerpt :An alternative explanation for preferential Ins(1,4)P2generation in the heart is that Ins(1,4)P2 itself has a signaling function. While Ins(1,4)P2 is generally considered to be an inactive metabolite of Ins(1,4,5)P3, there have been a number of studies suggesting that it has a role in cellular growth (42, 43) and other metabolic pathways (44, 45). Clearly, further investigation would be required to establish any such role in the heart.
The generation of lipid signaling molecules in the nucleus
1999, Progress in Lipid Research