ArticlesEfficacy of immunochemotherapy as adjuvant treatment after curative resection of gastric cancer
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Anticarcinogenic potential of the mushroom polysaccharide lentinan on gastric and colon cancer cells: Antiproliferative, antitumorigenic, Mu-2-related death-inducing gene, MUDENG ramifications
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2022, Carbohydrate PolymersCitation Excerpt :Moreover, due to their low toxicity and rarity of side effects, natural polysaccharides have been extensively studied as a class of potential anti-tumor agents (Yu, Shen, Song, & Xie, 2018). Several polysaccharide extracts from plants, animals, and fungi have been approved for the adjuvant treatment of cancers in clinical trials, including Poria cocos polysaccharide, Lentinan, Ginseng polysaccharide, and Polysaccharide Kreha (PSK) (Nakazato, Koike, Saji, Ogawa, & Sakamoto, 1994; Yu et al., 2018). Poria cocos polysaccharide oral solution, which has been provided as an over-the-counter health care product for decades in China, has been approved by the National Medical Products Administration as a drug for cancer treatment (Li et al., 2019).
Immunomodulatory and antiinflammatory activities of terrestrial fungal polysaccharides: A review
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2017, Trends in Pharmacological SciencesImmunochemotherapy benefits in gastric cancer patients stratified by programmed death-1 ligand-1
2017, Journal of Surgical ResearchCitation Excerpt :The results of this meta-analysis suggest that adjuvant immunochemotherapy with PSK improves the survival of patients after curative resection (HR: 0.88; 95% CI: 0.79-0.98; P = 0.018).15 Studies also showed that administration of PSK was able to reduce the risk of cancer-related death by up to 38% for stage II and III patients.10,16 Our subpopulation analysis, which took various stages of the disease and PD-L1 expression into account, might partly explain the mixed results of the previous surgical series.15,17
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Participating centres and other investigators are listed at the end of the article.