Elsevier

The Lancet

Volume 362, Issue 9378, 12 July 2003, Pages 128-130
The Lancet

Research Letters
Distribution of codon 129 genotype in human growth hormone-treated CJD patients in France and the UK

https://doi.org/10.1016/S0140-6736(03)13867-6Get rights and content

Summary

Since homozygosity MM at codon 129 of the prion protein gene is a recognised risk factor in all forms of Creutzfeldt-Jakob disease (CJD), we studied the distribution of codon 129 polymorphism in patients in France and in the UK with CJD transmitted iatrogenically by human growth hormone. The overall frequencies of codon 129 genotypes in these patients differed from those in the population unaffected by CJD. An excess of W homozygotes was noted among those with iatrogenic CJD compared with sporadic CJD cases. The proportion of MM genotype in UK patients was surprisingly low (4%) compared with that in French patients (62%). There is no evident explanation for this different distribution, which might be due to infection with different strains of prion in human growth hormone.

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