Preliminary CommunicationsPERSISTENCE OF DRUG-RESISTANT MALARIA PARASITES
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Cited by (42)
Fitness of sulfadoxine-resistant Plasmodium berghei harboring a single mutation in dihydropteroate synthase (DHPS)
2021, Acta TropicaCitation Excerpt :No in vivo experiment to assess the fitness of sulfadoxine-resistant parasites had been performed so far. Although some have been reported for pyrimethamine (Rosario et al., 1978; Shinondo et al., 1994), the results were, however, not consistent; one study reported a similar fitness between sulfadoxine-resistant and -susceptible P. berghei parasites in the absence of pyrimethamine (Shinondo et al., 1994), whereas this was not observed in another study using P. chabaudi (Rosario et al., 1978). Apart from the difference in Plasmodium species used for the experiments, one reason for this inconsistency could be the potential occurrence of additional genetic changes that compensate for the fitness impairment imposed by drug resistance.
Virulence and drug resistance in malaria parasites
2009, Trends in ParasitologyCitation Excerpt :For example, pyrimethamine resistant P. berghei strains seem to have a transmission disadvantage under drug-free conditions as compared to pyrimethamine sensitive strains from the same genetic background [7]. Similarly, a pyrimethamine-sensitive P. chabaudi strain outgrew a pyrimethamine-resistant isogenic strain in mice in two out of three experiments [8]. These data are explained by resistant parasites carrying mutational changes in key factors that, while allowing the parasite to evade the deleterious effects of the drug, compromise their natural physiological function(s).
Drug resistance-virulence relationship in Plasmodium falciparum causing severe malaria in an area of seasonal and unstable transmission
2006, Acta TropicaCitation Excerpt :Studies in rodent malaria parasites have demonstrated a potential fitness burden of drug resistance. A pyrimethamine-resistant mutant P. chabaudi was found to grow slower than its sensitive progenitor and in a mixture the sensitive clone outgrew the mutant form (Walliker et al., 2005), although in another study the resistant parasite was found to grow as well as its sensitive parent (Rosario et al., 1978). In P. berghei, a pyrimethamine-resistant clone was found to produce sporozoites more slowly in mosquitoes compared to the sensitive form (Shinondo et al., 1994).
Estimating SNP proportions in populations of malaria parasites by sequencing: Validation and applications
2005, Molecular and Biochemical ParasitologyFitness of drug-resistant malaria parasites
2005, Acta TropicaCitation Excerpt :In an early study, the fitness of a pyrimethamine-resistant mutant clone of the rodent malaria species Plasmodium chabaudi was studied by examining its growth in mixed infections with its sensitive progenitor in mice. Clones were subsequently established from the mixed infections at various stages up to 30 days, each of which was tested for pyrimethamine response (Rosario et al., 1978). The sensitive parent appeared to outgrow the mutant in two mixtures, while in a third experiment, more resistant than sensitive forms survived.