Elsevier

The Lancet

Volume 311, Issue 8057, 28 January 1978, Pages 185-187
The Lancet

Preliminary Communications
PERSISTENCE OF DRUG-RESISTANT MALARIA PARASITES

https://doi.org/10.1016/S0140-6736(78)90616-5Get rights and content

Abstract

Mixtures of drug-resistant and sensitive forms of Plasmodium chabaudi were used to infect mice, and the resulting infections were maintained in the absence of drug. Both chloroquine-resistant and pyrimethamine-resistant mutants were able to survive in such mixed infections. The results of experiments on chloroquine resistance indicated an apparent selective advantage of the resistant over the sensitive form.

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