Association of angiotensinogen gene T235 variant with increased risk of coronary heart disease
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Cited by (325)
Angiotensinogen: More Than its Downstream Products: Evidence From Population Studies and Novel Therapeutics
2022, JACC: Heart FailureCitation Excerpt :For these reasons, genetic association studies between angiotensinogen single-nucleotide polymorphisms (SNPs) and CVD have been the primary means of investigation in population studies.8,53,54 The key SNPs that have been repeatedly found to have an association with CVD in large scale studies are SNP M235T or (reference SNP ID rs699), SNP T174M (or rs4762), and SNP G(-6)A (or rs5051) (Figure 5, Table 1).8-10,17 SNP M235T (rs699) is a missense variant that has been associated with an increase in angiotensinogen plasma concentration,55,56 an increased incidence of hypertension,10,57,58 and higher mortality related to heart failure.60-63
Angiotensinogen and angiotensins
2018, Encyclopedia of Endocrine DiseasesAssociation of angiotensin-converting enzyme polymorphism with coronary artery disease in Iranian patients with unipolar depression
2012, Clinical BiochemistryCitation Excerpt :Statistical analysis of the mentioned SNPs on the ACE and AGT genes individually also showed no association with CAD in depressed patients. Several studies have reported association of AGT M235T polymorphism with CAD [42,43] while a meta-analysis, including twelve studies, has demonstrated no association in this regard [69]. Thus, the lack of relationship between AGT M235T polymorphism and CAD in depressed Iranian individuals is consistent with the results reported by some other studies carried out in low risk populations.
Polymorphisms of angiotensin II type 1 receptor gene and those of angiotensinogen point at culprit artery in ST-segment elevation myocardial infarction
2012, GeneCitation Excerpt :Results are presented in Table 1. In patients with diagnosed coronary artery disease, RAS gene polymorphisms were examined mainly in terms of the risk for coronary artery disease or acute MI (Katsuya et al., 1995; Tiret et al., 1994). Nakauchi et al. found that the number of affected vessels was significantly greater in patients with the AC genotype for AGTR1 1166A/C gene polymorphism than in those with the AA genotype (1.93 vs 1.27, p < 0.05) (Nakauchi et al., 1996).