Risk factor analysis of hypersensitivity reactions to abacavir
References (8)
- et al.
Idiosyncratic drug reactions: The reactive metabolite syndromes
Lancet
(2000) - et al.
Hypersensitivity reactions during therapy with the nucleoside reverse transcriptase inhibitor abacavir
Clin Ther
(2001) - et al.
Adverse events from drug therapy for human immunodeficiency virus disease
Am J Med
(1996) - et al.
Unique intracellular activation of the potent anti-human immunodeficiency virus agent 1592U89
Antimicrob Agents Chemother
(1997)
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2016, Journal of Virological MethodsCitation Excerpt :In such cases, death may occur, if dosing is continued or if ABC is re-challenged (Hughes et al., 2008). Genetic research has shown that HSR to ABC in Caucasian HIV-1 infected patients was significantly associated with carriage of the HLA-B*57:01 allele (Symonds et al., 2002; Mallal et al., 2002). The PREDICT-1 trial demonstrated that prospective screening of HLA-B*57:01 prevented entirely the occurrence of ABC HSR among HIV-1 infected Caucasians in Europe and in Australia (Mallal et al., 2008).