Limbic-striatal interactions in reward-related processes

doi:10.1016/S0149-7634(89)80025-9

Neuroscience & Biobehavioral Reviews

Volume 13, Issues 2–3, Summer–Autumn 1989, Pages 155-162

https://doi.org/10.1016/S0149-7634(89)80025-9 Get rights and content

Stimuli with formerly motivationally neutral properties gain incentive properties from their predictive association with primary reinforcement, and are termed conditioned reinforcers. Infusions of the indirect dopamine (DA) agonist d-amphetamine into the ventral striatum selectively enhanced responding for a light that was positively correlated with water. These selective stimulatory effects were blocked by 6-OHDA lesions of the ventral, but not dorsal striatum, and resembled those produced by DA itself when infused into the ventral striatum. However, the choice of the lever producing the conditioned reinforcer was not affected by ventral striatal DA depletion. This choice was, however, attenuated by excitotoxic lesions of the basolateral nucleus of the amygdala, suggesting an interaction between this structure and DA-dependent processes of the ventral striatum in the processes by which reward-related stimuli come to affect action. Parallel findings were obtained using a second order schedule of sexual reinforcement. Other observations indicated that the amygdala lesion did not impair the discriminative property of the reward-related stimuli, or affect primary motivation. Experiments using explicit conditional visuo-spatial discrimination tasks suggest that similar discriminative properties are preserved following DA depletion from the ventral, but not the dorsal, striatum. These results possibly represent a dissociation between stimulus-response (or habit) and stimulus-reward associative mechanisms, modulated respectively by the dorsal and ventral striatum.

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²: Permanent address: INSERM U 259, Rue Camille St Saens, Université de Bordeaux II, Bordeaux Cedex 33077, France.

³: Present address: Department of Psychiatry, Yale University, New Haven, CT 06520.

⁴: Department of Anatomy, University of Cambridge, U.K.

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ArticleLimbic-striatal interactions in reward-related processes

Neuroscience

Neuroscience

Physiol. Behav.

Exp. Neurol.

Neuroscience

Pharmacol. Biochem. Behav.

Prog. Neurobiol.

Int. Rev. Neurobiol.

Neuropharmacology

Pimozide blocks establishment but not expression of amphetamine-produced environmental conditioning

Science

The effects of pipradrol on responding with conditioned reinforcement: a role for sensory pre-conditioning

Psychopharmacology (Berlin)

A unified interpretation of emotion and motivation

Ann. NY Acad. Sci.

Conditioned place preference from intra-accumbens amphetamine but not from intra-caudate amphetamine injection

Life Sci.

Double dissociations of the effects of amygdala and insular cortex lesions on conditioned taste aversion, passive avoidance and neophobia in the rat using the excitotoxin ibotenic acid

Behav. Neurosci.

Studies of instrumental behavior with sexual reinforcement in male rats Rattus norvegicus. I. Control by brief visual stimuli paired with a receptive female

J. Comp. Psychol.

Studies of instrumental behavior with sexual reinforcement in male rats, Rattus norvegicus. II Effects of preoptic area lesions, castration and testosterone

J. Comp. Psychol.

Reward, motivation and cognition: psychobiology of the mesotelencephalic dopamine systems

Article
Limbic-striatal interactions in reward-related processes