T-cell and T/natural killer-cell lymphomas involving ocular and ocular adnexal tissues: A clinicopathologic, immunohistochemical, and molecular study of seven cases
Section snippets
Case histories
A summary of the relevant clinical information is presented in Table 1.
Tissue samples
Collections on file in the Departments of Pathology, Western Infirmary, Glasgow, Scotland, and the University Hospital Benjamin Franklin, Berlin, Germany, as well as those in the Departments of Ophthalmology, University Hospital Freiburg, Germany, and the University of Maryland School of Medicine, Baltimore, Maryland, were reviewed. Cases of mycosis fungoides were excluded. Most tissue biopsy specimens had been fixed in 4% formaldehyde solution and embedded in paraffin; some biopsy specimens
Results
The results of the immunohistochemical, in situ hybridization, and molecular biologic findings of the cases examined are summarized in Table 2.
Discussion
Lymphomas with T-cell phenotype are uncommon, accounting for only 10% to 15% of all NHL.27 They represent a heterogeneous group of diseases differing in histopathologic analysis, tumor site, and cell origin. They include not only PTCLs derived from α/β cells but also some recently recognized entities such as T/NK-cell lymphomas and γ/δ-hepatosplenic lymphomas.5 The T-cell lymphomas are rare in ocular tissues and are represented predominantly by mycosis fungoides and secondary manifestations of
Acknowledgements
The authors thank Dr. A. Hidayat, who was involved in the diagnosis of case 6; Dr. A. Kapp for his assistance in obtaining clinical information; as well as Mr. H-H. Müller, Mrs. H. Protz, and Miss D. Jahnke for their supportive technical assistance.
References (57)
- et al.
Lymphoproliferative lesions of the ocular adnexa. Analysis of 112 cases
Ophthalmology
(1998) - et al.
B- and T-lymphocytes in ocular disease
Ophthalmology
(1984) - et al.
Ocular adnexal lymphoma. A clinicopathologic study with identification of lymphomas of mucosa-associated lymphoid tissue type
Ophthalmology
(1995) - et al.
A revised European-American classification of lymphoid neoplasmsa proposal from the International Lymphoma Study Group
Blood
(1994) - et al.
T-cell lymphoma of the orbit
Mayo Clin Proc
(1989) - et al.
Immunoblastic T-cell lymphoma presenting as an eyelid tumor
Ophthalmology
(1990) - et al.
Primary T-cell immunoblastic lymphoma of the orbit in a pediatric patient
Ophthalmology
(1993) - et al.
Mycosis fungoides of upper lid
Am J Ophthalmol
(1968) - et al.
Mycosis fungoides involving the caruncle
Am J Ophthalmol
(1969) - et al.
Cutaneous T-cell lymphoma presenting as a rapidly enlarging ocular adnexal tumor
Ophthalmology
(1985)
Ocular manifestations of adult T-cell leukemia/lymphoma
A clinicopathologic study. Ophthalmology
Adult T-cell leukemiaclinical and hematologic features of 16 cases
Blood
Intraocular lymphoma. Clinical and histopathologic diagnosis
Ophthalmology
Lymphoid hyperplasia and malignant lymphoma occurring in the ocular adnexa (orbit, conjunctiva, and eyelids)a prospective multiparametric analysis of 108 cases during 1977 to 1987
Hum Pathol
Testicular lymphoma: a population-based study of incidence, clinicopathological correlations and prognosis. The Danish Lymphoma Study Group, LYFO
Eur J Cancer
Malignant lymphoma of the testis
Am J Med
Malignant lymphoma of the testishistological and immunohistological study of 28 cases
J Urol
Anaplastic large-cell lymphomas of T-cell and null-cell phenotype express cytotoxic molecules
Blood
Solitary extranodal anaplastic large cell lymphoma, Ki-1+, of the eyelid
Am J Ophthalmol
EORTC classification for primary cutaneous lymphomasa proposal from the Cutaneous Lymphoma Study Group of the European Organization for Research and Treatment of Cancer
Blood
Nonnasal lymphoma expressing the natural killer cell marker CD56a clinicopathologic study of 49 cases of an uncommon aggressive neoplasm
Blood
T- and T/natural killer-cell lymphomas of the salivary glanda clinicopathologic, immunohistochemical and molecular study of six cases
Hum Pathol
Ocular involvement in Epstein-Barr virus-associated T-cell lymphoma
Am J Ophthalmol
The clinical spectrum of ocular lymphoma
Cancer
Immunological characterization of an ocular adnexal lymphoid T tumor by monoclonal antibodies
Ophthalmologica
Lid und Orbitabeteiligung bei Mycosis fungoides
Klin Monatsbl Augenheilkd
Localisation palpébrale d’un mycosis fongöide. Attitude thérapeutique
Bull Soc Ophtalmol Fr
Bilateral orbital infiltration as the initial sign of a peripheral T-cell lymphoma presenting in a leukemic phase
Ann Ophthalmol
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