Intestinal metallothionein and the mutual antagonism between copper and zinc in the rat
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Biometals in Autism Spectrum Disorders
2020, Biometals in Autism Spectrum DisordersCopper imbalance in Alzheimer's disease: Convergence of the chemistry and the clinic
2019, Coordination Chemistry ReviewsCitation Excerpt :In the brain, copper is also centrally involved in catecholamine synthesis via dopamine β-hydroxylase (DBH), catecholamine degradation via monoamine oxidase (MAO), neuropeptide synthesis via peptidylglycine α-amidating monooxygenase, glutamatergic synapse modulation, excitotoxicity, and myelin formation [14,135]. Via its antagonistic relationship to zinc managed by the metallothioneins, copper also affects zinc levels and associated processes [38,145–148], which again affects calcium levels [149,150]. Via ceruloplasmin, copper modulates iron uptake and distribution by influencing the oxidative state of iron, since ceruloplasmin catalyzes the oxidation of Fe(II) to Fe(III), which is then loaded into transferrin [54,151].
Effect of Cu<sup>2+</sup> and Zn<sup>2+</sup> ions on human serum albumin interaction with plasma unsaturated fatty acids
2019, International Journal of Biological MacromoleculesCitation Excerpt :Overall, zinc and copper play antagonistic biological roles owing to their similar chemical and physical properties, which leads to Zn2+ and Cu2+ competition for the same binding sites of enzymes and transport proteins [62,63]. Excessive zinc intake inhibits intestinal absorption and hepatic accumulation of copper, reduces activity of Cu2+-dependent enzymes, and induces signs of copper deficiency [63–66]. Therefore Zn2+ is used for inhibition of intestinal absorption of Cu2+ in Wilson's disease [67].
History of Wilson Disease
2019, Wilson Disease: Pathogenesis, Molecular Mechanisms, Diagnosis, Treatment and MonitoringAlzheimer's disease: How metal ions define β-amyloid function
2017, Coordination Chemistry ReviewsDiscovery of Zinc for Human Health and Biomarkers of Zinc Deficiency
2017, Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals