T lymphocyte mediated protection against facultative intracellular bacteria
References (45)
- et al.
Trends Microbiol.
(1993) - et al.
Biochim. Biophys. Acta
(1992) - et al.
Gene
(1994) - et al.
Cell. Immunol.
(1982) - et al.
Microb. Pathog.
(1992) - et al.
J. Bacteriol.
(1993) - et al.
J. Immunol.
(1989) - et al.
Infect. Immun.
(1994) - et al.
Biochemistry
(1990) - et al.
AIDS Res. Hum. Retroviruses
(1992)
Infect. Immun.
Infect. Immun.
Infect. Immun.
Infect. Immun.
Infect. Immun.
J. Hyg.
J. Infect. Dis.
Infect. Immun.
DNA
Infect. Immun.
Infect. Immun.
Cited by (43)
Polymeric antigen BLSOmp31 formulated with class B CpG-ODN in a nanostructure (BLSOmp31/CpG-ODN/Coa-ASC16) administered by parenteral or mucosal routes confers protection against Brucella ovis in Balb/c mice
2021, Research in Veterinary ScienceCitation Excerpt :Mucosal immunization using either formulation has induced systemic IgG and IgA antibodies and significant specific cellular immune responses, conferring partial protection and preventing the excretion of B. ovis in semen (Díaz et al., 2016a; Díaz et al., 2016b; Díaz et al., 2019). Since the protective immune response against Brucella infections requires the induction of a potent cell-mediated immunity, an effective brucellosis vaccine should stimulate Th1 cells, the main gamma interferon (IFN-γ) producer subpopulation (Splitter et al., 1996). Synthetic oligodeoxynucleotides containing unmethylated cytosine-guanine motifs (CpG-ODN) is an agonist of the endosomal Toll-like receptor 9 (TLR9) (Mogensen, 2009).
Association between polymorphisms of cytokine genes and brucellosis: A comprehensive systematic review and meta-analysis
2020, CytokineCitation Excerpt :An important aspect in the pathogenesis of Brucella, apart from its virulence factors and the environmental factors contributing to infection, is host genetic background, which is crucial in determining the susceptibility or resistance to brucellosis [10]. Cell-mediated and humoral immune responses, in which several cytokines are involved, play pivotal roles in protection against brucellosis [11–16]. Production and release of cytokines rely mostly on human genetic factors, so variations in the regulatory sequences of the cytokine genes can greatly affect the cytokine balance.
Recombinant outer membrane protein 25c from Brucella abortus induces Th1 and Th2 mediated protection against Brucella abortus infection in mouse model
2018, Molecular ImmunologyCitation Excerpt :The capability of this bacteria to survive, replicate and persist within phagocytes, including macrophages, dendritic cells (DCs) and placental trophoblasts, makes it a potent pathogen (Salcedo et al., 2008; Archambaud et al., 2010; Copin et al., 2012). To achieve this, the bacterium has inherent strategies of resisting and escaping the killing mechanisms of phagocytic cells and inhibiting the elicitation of host immune response (Splitter et al., 1996). Furthermore, intracellular lifestyle of Brucella and acidic environment surrounding the bacteria within the host cell limits the innate and adaptive immune responses (Martirosyan and Gorvel, 2013); in turn helps them to evade from the action of antibiotic therapy (de Figueiredo et al., 2015).
Monocyte-derived macrophages from Zebu (Bos taurus indicus) are more efficient to control Brucella abortus intracellular survival than macrophages from European cattle (Bos taurus taurus)
2013, Veterinary Immunology and ImmunopathologyCitation Excerpt :Activation of Th1 lymphocytes response is due to stimulation by macrophage-secreted IL-12 during B. abortus infection in vitro and in vivo (Jones and Winter, 1992; Jiang and Baldwin, 1993). Interferon γ (IFN-γ) is one of the most important cytokine synthesized by Th1 lymphocytes, and it is widely described as major activator of macrophage antibacterial functions (Jiang and Baldwin, 1993; Splitter et al., 1996; Oliveira et al., 2002). Furthermore, IL-12 is involved in adaptive immune response by direct stimulation of cytotoxic activity by CD8+ T lymphocytes (Zhan et al., 1996).
Immunoproteomic analysis of Brucella melitensis and identification of a new immunogenic candidate protein for the development of brucellosis subunit vaccine
2011, Molecular ImmunologyCitation Excerpt :The result indicated that RS-α per se is a powerful immunogen that is able to induce high titers of specific antibodies. The levels of splenocyte proliferation in immunized mice with Brucella protein antigens has been previously reported, such as a fraction containing 26 and 28 kDa proteins (Splitter et al., 1996), Cu–Zn superoxide dismutase (Andrews et al., 2006), L7/L12 (Luo et al., 2006b), and P39 (Vizcaino et al., 1996). In the present study, the SI in groups receiving rRS-α and standard vaccine Rev.1 were all significantly higher than the control group (P < 0.05) (Fig. 4).