Research reportThe molarless condition in aged SAMP8 mice attenuates hippocampal Fos induction linked to water maze performance
Section snippets
Acknowledgements
This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan (11671960; 12557173), and an Esso Research Grant for Women (to K.W.). We also express our deep gratitude to K. Hasegawa for his encouragement and co-operation during the course of this work.
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2018, Kaohsiung Journal of Medical SciencesCitation Excerpt :Affections from primary connections in the trigeminal ganglion toward the secondary neurons of spinal and midbrain neuclei, ascending to the thalamus and connecting to and integrating with the hippocampus, prefrontal cortices, and precuneus as well as somatosensory and motor cortices in the lesion projection zone can further affect local circuitry, regional and global networks. DD is shown by both animal and clinical researches to have a positive association with memory and cognitive status [12–30,41–53,63–65]. The conversion rate from MCI to dementia is reportedly 20–50% within 5 years [66,67].