Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
Short sequence-paperAn orphan nuclear receptor lacking a zinc-finger DNA-binding domain: interaction with several nuclear receptors1
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Cited by (48)
FXR in liver physiology: Multiple faces to regulate liver metabolism
2021, Biochimica et Biophysica Acta - Molecular Basis of DiseaseCitation Excerpt :On the other hand SHP shows direct transcriptional repression [62]. From a metabolic point of view, the most important interacting partners for SHP are HNF4 and RXR [63], LRH-1 [62], LXRα and consequently a blunted SREBP-1c activation [64], PGC1α [65], CAR [61] and PPARα [66]. Therefore, FXR mediated SHP activation has profound physiological effects on bile acid, lipid and glucose homeostasis.
Bile acids down-regulate the expression of Augmenter of Liver Regeneration (ALR) via SHP/HNF4α1 and independent of Egr-1
2018, Experimental and Molecular PathologyPostprandial response and tissue distribution of the bile acid synthesis-related genes, cyp7a1, cyp8b1 and shp, in rainbow trout Oncorhynchus mykiss
2013, Comparative Biochemistry and Physiology - A Molecular and Integrative PhysiologyRetinoic Acid-mediated Nuclear Receptor Activation and Hepatocyte Proliferation
2009, Journal of Experimental and Clinical MedicineInteraction between sterol regulatory element-binding proteins and liver receptor homolog-1 reciprocally suppresses their transcriptional activities
2007, Journal of Biological ChemistryCitation Excerpt :It is likely that this alternative pathway may play an important role in the regulation of human bile acid biosynthesis, because the human CYP7A1 promoter lacks functional liver X receptor-binding sites (38) critical for the induction of rodent CYP7A1 gene expression in response to hepatic cholesterol accumulation (Fig. 7). Moreover, the SREBP-mediated regulation of SHP gene expression, as shown in the current study, must play a critical role in controlling lipid homeostasis in the liver in light of the fact that SHP affects the transcriptional activities of several nuclear receptors deeply involved in lipid metabolism (10–15). The previous study demonstrated that SREBPs directly interact with the ligand-binding domain of HNF-4, thereby inhibiting the recruitment of a coactivator protein, PGC-1α, and attenuating the transcriptional activity of HNF-4 (39).
Structure and Function of the Atypical Orphan Nuclear Receptor Small Heterodimer Partner
2007, International Review of CytologyCitation Excerpt :SHP is also detected in mouse mesenteric, epididymal, and subcutaneous fat tissues by reverse transcriptase polymerase chain reaction (RT‐PCR) (Nishizawa et al., 2002). Rat SHP mRNA was detected in the liver, heart, and to a lesser extent in skeletal muscle, kidney, testis, lung, and spleen by Northern analysis (Masuda et al., 1997). It was also detected in the epididymis, prostate, testis, uterus, colon, small intestine, bladder, stomach, spleen, lung, liver, thymus, heart, adrenal, spinal cord, olfactory lobes, and cerebellum (Johansson et al., 1999).
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The present nucleotide sequences are available on the DDBJ/EMBL/GenBank databases with the accession numbers D86580 (cDNA), D86745 (genomic sequence around exon 1), and D86839 (genomic sequence around exon 2).