Oral tolerance: immune mechanisms and treatment of autoimmune diseases

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Abstract

Orally administered proteins induce systemic hyporesponsiveness to the fed protein. The mechanism underlying such ‘oral tolerance’ depends on the amount of antigen fed. with higher doses inducing deletion and anergy, and lower doses inducing regulatory cells. Orally administered autoantigens suppress many experimental autoimmune diseases, as discussed here by Howard Weiner.

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