Selenium, zinc and copper plasma levels in intrahepatic cholestasis of pregnancy, in normal pregnancies and in healthy individuals, in Chile
Section snippets
Population samples
Patients with intrahepatic cholestasis of pregnancy (ICP): During 1994–1995, 21 ICP patients hospitalized in the obstetric wards of our hospital, were selected for this study. All were inhabitants of the Eastern District of Santiago, and their ethnic and socio-economic characteristics were similar to the control groups.
The diagnosis of ICP was based on the finding of pruritus appearing during the second half of pregnancy, without skin lesions before scratching, plus abnormal serum levels of at
Clinical and laboratory characteristics of the main population samples (Table 1)
Age and parity were similar in the main groups included in this study: healthy women (non-pregnant or in the 3rd trimester of a normal pregnancy) and in patients with ICP.
Serum liver tests remained normal during the third trimester of normal pregnancies, with the exceptions of an increase in serum total alkaline phosphatases and a decrease in serum total protein and albumin concentrations.
Patients with ICP had significantly higher mean values of serum total bilirubin, both aminotransferases and
Discussion
The present study shows that in 1994–1995 the concentration of Se in plasma of healthy adults living in Santiago, Chile was significantly higher than 5–7 years before, using identical methodology and measured by the same investigators. This observation includes a comparison between similar groups of non-pregnant women and also an intragroup comparison in a small number of women and men who were studied twice, with a 9-year interval.
The concentration of Se in blood from healthy individuals is
Acknowledgements
This work was supported by FONDECYT (Chile), grants 1940420 and 1970915. We are grateful to the obstetricians, midwives and nurses from the Department of Obstetrics, Hospital del Salvador, and the Consultorio Lo Barnechea, Santiago, for allowing us to study patients under their care. The authors are also indebted to Raymond F. Burk, M.D. (Vanderbilt University, Nashville, TN, USA) for useful comments and criticisms.
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