Trends in Genetics
Volume 11, Issue 7, July 1995, Pages 268-272
Journal home page for Trends in Genetics

Review
Pax6: more than meets the eye

https://doi.org/10.1016/S0168-9525(00)89073-3Get rights and content

The paired-box motif, originally defined in Drosophila segmentation genes, is conserved in the Pax family of vertebrate developmental genes. Mutations that reduce Pax6 dosage cause dominantly inherited eye malformations in man and mouse. Remarkably, it has now been found that Drosophila has a homologue of Pax6, which also plays a key role in eye development.

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