Trends in Genetics
Volume 15, Issue 3, 1 March 1999, Pages 98-103
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Review
Making sense of the COP9 signalosome: a regulatory protein complex conserved from Arabidopsis to human

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Abstract

The COP9 signalosome, once defined as a repressor complex of light-activated development in Arabidopsis, has recently been found in humans and is probably present in most multicellular organisms. The COP9 signalosome is closely related to the lid sub-complex of the 26S proteasome in structural composition and probably shares a common evolutionary ancestor. A multifaceted role of the COP9 signalosome in cell-signaling processes is hinted at by its associated novel kinase activity, as well as the involvement of its subunits in regulating multiple cell-signaling pathways and cell-cycle progression. The molecular genetic studies in Arabidopsis suggest that the complex functions as part of a highly conserved regulatory network, whose physiological role in animals remains to be determined.

Keywords

Cell biology
Biochemistry
Evolution
Genetics
Plant biology

Keywords

signal transduction
plant
development
cell cycle
proteolysis

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