Do primary small intestinal melanomas exist? Report of a case☆,☆☆
Section snippets
CASE REPORT
A 41-year-old white woman presented with signs and symptoms of a partial small bowel obstruction. She had a history of chronic and intermittently severe abdominal pain associated with weight loss and diarrhea for 5 years and had been treated unsuccessfully for peptic ulcer disease with antacids, omeprazole, sucralfate, metoclopramide, and H2 antagonists. The small bowel obstruction symptoms cleared spontaneously, but 1 week later she presented with similar symptoms and underwent an exploratory
DISCUSSION
The clinical findings of melanoma involving the gastrointestinal tract are variable ranging from clinically undetectable to symptomatic. The most frequent symptoms reported include cramping, abdominal pain related to obstruction, melena, anorexia, weight loss, vomiting, and constipation.4, 5, 8, 9 Gastrointestinal metastases are usually clinically undetectable in the early stages and require a high index of suspicion with a focused gastrointestinal review of symptoms. At autopsy, small
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Gastro-intestinal metastasis from Melanoma: Clinico-pathological clues
2023, Pathology Research and PracticeCitation Excerpt :In absence of MM oncological anamnesis, as in 8/49 of our patients, a differential diagnosis with primary GI MM should be proposed. Briefly, primary MM in the GI tract is diagnosed if there is 1) biopsy-proven melanoma at a single focus; 2) lack of evidence of disease in any other organs including the skin, eye and lymph nodes outside the region of drainage at the time of diagnosis or previously; and 3) disease-free survival of at least 12 months after diagnosis [10,11]. According to these diagnostic criteria, we confidentially excluded primary GI MM due to the presence of multivisceral and/or multifocal involvement at the time of diagnosis in our 8 cases.
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