Original ArticlesChanges in behavior and muscarinic receptor density after neonatal and adult exposure to bioallethrin
Section snippets
Animals and chemicals
Pregnant Naval Medical Research Institute (NMRI) mice were obtained from B&K, Sollentuna, Sweden. Subsequently, each litter, adjusted within 48 h to 8–12 pups, was kept together with its respective dam in a plastic cage in a room at 22°C and a 12/12 h light/dark cycle. At the age of 4 weeks, pups were weaned and males were placed and raised in groups of four to seven in a room for male mice only. Animals were supplied with standardized pellet food and tap water ad libitum. Bioallethrin
Results
No clinical signs of toxic symptoms were observed in mice of the different treatment groups throughout the experimental period. Nor were there any significant differences in weight gain.
Animals treated with bioallethrin both as neonates and as adults had as their control group animals treated with bioallethrin as neonates and vehicle as adults. Animals treated with vehicle as neonates and with bioallethrin as adults had as their control group animals treated with vehicle both as neonates and as
Discussion
The present study revealed in adult mice exposed neonatally to bioallethrin an increased susceptibility to develop permanent changes in muscarinic acetylcholine receptor density and behavior when subsequently exposed as adults to the same agent. The group exposed both neonatally and as adults to bioallethrin showed modified spontaneous behavior accompanied by a changed swim maze performance. The density of muscarinic receptors was also significantly increased in this group.
The spontaneous motor
Acknowledgements
The authors thank Dr. Tessier, Rousell Uclaf, France, for the gift of bioallethrin and Anna Pettersson for excellent technical assistance. This work was financially supported by grants from the Swedish Environmental Protection Board, The Swedish Work Environmental Fund, and the Bank of Sweden Tercentenary Foundation.
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