PaperEvaluation of the safety, reactogenicity and immunogenicity of three recombinant outer surface protein (OspA) lyme vaccines in healthy adults
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2013, The Lancet Infectious DiseasesCitation Excerpt :With respect to the inverse dose response after the booster immunisation, a reduced antigen dose might be sufficient to induce substantial antibody titres. However, in previous studies of a monovalent OspA-1 vaccine, substantially higher antibody titres were reported for a 30 μg adjuvanted dose24 than for a 10 μg adjuvanted dose.25 The safety and immunogenicity of monovalent OspA-1 vaccines formulated with or without adjuvant have been investigated in several previous studies.9,10,24,26–29
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