Management of warfarin (coumarin) overdose
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2016, Medicine (United Kingdom)Citation Excerpt :When these are suspected, a full blood count and coagulation screen are indicated. In warfarin and difenacoum poisoning, the prothrombin time and international normalized ratio are elevated, and may remain so for weeks with difenacoum.9 Air, water and food-borne poisoning should be considered when clustering of cases occurs.
Use and effectiveness of prothrombin complex concentrates vs fresh frozen plasma in gastrointestinal hemorrhage due to warfarin usage in the ED
2014, American Journal of Emergency MedicineMolecular displacement of warfarin from human serum albumin by flavonoid aglycones
2013, Journal of LuminescenceCitation Excerpt :This property is coupled with a narrow therapeutic window therefore displacing of warfarin from human serum albumin (HSA) can result in the occurrence of unexpected bleedings. Because of the delicate balance of bound and unbound forms of warfarin in the human organism its molecular interactions is of very high importance [5,6]. Metabolism of warfarin is mainly driven by Cytochrome P450 (CYP450) enzymes (for example CYP2C9) [7].
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