Progress in Neuro-Psychopharmacology and Biological Psychiatry
Magnetic resonance imaging and spectroscopy in offspring at risk for schizophrenia: Preliminary studies
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Cited by (124)
A potential objective marker in first-episode schizophrenia based on abnormal niacin response
2022, Schizophrenia ResearchIncreased amygdala and decreased hippocampus volume after schedule-induced polydipsia in high drinker compulsive rats
2020, Behavioural Brain ResearchMagnetic resonance spectroscopy studies in subjects with high risk for psychosis: A meta-analysis and review
2020, Journal of Psychiatric ResearchMedial temporal lobe default mode functioning and hippocampal structure as vulnerability indicators for schizophrenia: A MRI study of non-psychotic adolescent first-degree relatives
2014, Schizophrenia ResearchCitation Excerpt :The neuroimaging studies of younger relatives under the age of 30 consistently identify MTL alterations compared to controls (cf. review by Thermenos et al., 2013) with few negative findings (Karnik-Henry et al., 2012). Early studies demonstrated a smaller “amygdala–hippocampal complex” in youth at familial high-risk (FHR), in which the amygdala and hippocampus were not separated due to existing limitations of anatomical resolution and segmentation procedures (Keshavan et al., 1997, 2002; Schreiber et al., 1999; Lawrie et al., 2001). More recent studies have demonstrated smaller hippocampal volumes (Ho and Magnotta, 2010; Sismanlar et al., 2010; Francis et al., 2013) alterations in hippocampal white matter (Hao et al., 2009), right-left asymmetry (Qiu et al., 2009), and shape (Ho and Magnotta, 2010) in nonpsychotic relatives under the age of 30.
Hippocampus and amygdala volumes in children and young adults at high-risk of schizophrenia: Research synthesis
2014, Schizophrenia ResearchCitation Excerpt :Within the genetic risk paradigm, Boos et al. conducted a meta-analysis of family studies in schizophrenia and showed that first-degree relatives had lower hippocampal, total gray matter, and ventricular volumes, compared with healthy volunteers (Boos et al., 2007). Other studies considering only genetic risk provide an overview of brain changes in subjects with high risk for schizophrenia (Keshavan et al., 1997, 2002; Whalley et al., 2005; Lawrie et al., 2008; Moran et al., 2013) reporting abnormalities mainly in the frontal and temporal regions. To our knowledge, only Jung et al. have proceeded with systematically reviewing the literature for MRI studies considering all type of HR subjects (Jung et al., 2010).
Gray Matter Alterations in Schizophrenia High-Risk Youth and Early-Onset Schizophrenia. A Review of Structural MRI Findings.
2013, Child and Adolescent Psychiatric Clinics of North AmericaCitation Excerpt :In cross-sectional analyses, GHR youth have most consistently shown evidence for smaller PFC GM, including reduced cortical thickness,36–38 volume (inferior frontal gyrus,39–42 frontal pole,43 medial PFC43), or gyral surface area44 compared with controls. Other brain areas where GHR has reliably shown less GM compared with controls include: temporal cortex (decreased bilateral superior temporal gyrus [STG] volume45,46 and surface area,47 bilateral temporal lobe cortical thinning36,37), parietal cortex (decreased GM volume37,42,48 and reduced cortical thickness38,49), and medial temporal/limbic regions (hippocampus,50–55 parahippocampus,36,56 anterior cingulate cortex36,57). More variable findings have been reported with respect to smaller GM in GHR versus controls in occipital cortex, cerebellum, amygdala, thalamus, and basal ganglia.35