Variation of variable number of tandem repeat sequences in the 3′-untranslated region of primate dopamine transporter genes that affects reporter gene expression
Section snippets
Acknowledgements
This study was funded in part by Grants-in-Aid for Human Science and Longevity Science from the Ministry of Health and Welfare, the Cooperation Research Program of the Primate Research Institute, Kyoto University, a Grant-in-Aid for Scientific Research (No. 13740427) from the Ministry of Education, Culture, Sports, Science and Technology, and the Bio-oriented Technology Research Advancement Institution (BRAIN), Japan.
References (15)
- et al.
Genotype influences in vivo dopamine transporter availability in human striatum
Neuropsychopharmacology
(2000) - et al.
Dopamine transporter gene polymorphism and alcoholism
Biochem. Biophys. Res. Commun.
(1995) - et al.
The 3′ untranslated region of messenger RNA: a molecular ‘hotspot’ for pathology?
Nature Med.
(2000) - et al.
Evolution of nerve fiber degeneration in the striatum in the MPTP-treated squirrel monkey
Mol. Neurobiol.
(1994) - et al.
The VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expression
Pharmacogenomics J.
(2001) - et al.
Confirmation of association between attention deficit hyperactivity disorder and a dopamine transporter polymorphism
Mol. Psychiatry
(1997) - et al.
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
Nature
(1996)
Cited by (56)
Monoamine oxidase B rs1799836 G allele polymorphism is a risk factor for early development of levodopa-induced dyskinesia in Parkinson's disease
2020, eNeurologicalSciCitation Excerpt :Polymorphism genotyping for DAT rs28363170 was performed by fragment analysis. The genotype frequency of dopaminergic polymorphisms in the present study was confirmed against Japanese genotype frequency data from the NCBI database (https://www.ncbi.nlm.nih.gov) or previous studies [12–21] (Supplementary Table 1). Primers were designed by LightCycler Probe Design Software 2.0 (Roche Diagnostics).
DRD2/ANKK1 TaqIA and SLC6A3 VNTR polymorphisms in alcohol dependence: Association and gene-gene interaction study in a population of Central Italy
2012, Neuroscience LettersCitation Excerpt :To date, it is not exactly clear whether high or low levels of DAT are likely to predispose to alcoholism. Both the 9- and the 10-repeat alleles have been repeatedly associated with increased DAT expression and, as such, both may be treated as risk alleles [13,19,43]. In a general case–control design, the vast majority of studies did not find significant differences in SLC6A3 40 bp 3′UTR-VNTR distribution between alcohol dependent subjects and controls [42].